Thứ Năm, 27 tháng 9, 2018

Auto news on Youtube Sep 27 2018

Learning medicine is hard work!

Osmosis makes it easy.

It takes your lectures and notes to create a personalized study plan with exclusive videos,

practice questions and flashcards, and so much more.

Try it free today!

Leukodystrophy can be broken down.

Leuko- means "white", -dys means "abnormal" and -troph means "growth".

So, leukodystrophy means degeneration of the white matter of the brain, and that's the

part of the cerebral cortex that's filled with myelinated axons.

Myelin refers to the electrical insulation sheath around axons which allows neurons to

quickly send electrical impulses to one another.

Leukodystrophy is a dysmyelinating disease, meaning the structure of the myelin is abnormal,

and it's usually due to a genetic mutation.

In contrast, in a demyelinating diseases, previously normal myelin is damaged, like

in multiple sclerosis where the immune cells attack the myelin.

There are many different kinds of leukodystrophy, but the most common ones are Krabbe disease,

metachromatic leukodystrophy, and adrenoleukodystrophy.

The cerebral cortex is the largest region of the brain and it's responsible for sensory

and motor functions.

The cerebral cortex has an outer grey area and an inner white area.

The grey area, referred to as grey matter, houses neuron cell bodies.

And the white area, referred to as white matter, houses myelinated axons.

It is lighter because of the high fat content in myelin.

Neurons are the key cells that transmit neural impulses to one another through synapses.

Each neuron has dendrites, a cell body, and an axon.

Dendrites are the branches that first receive a neural impulse at a synapse with another

neuron.

The neural impulse passes through the cell body and goes through an axon, which projects

information away from the cell body to another cell.

Glial cells are support cells for neurons and they produce myelin to coat the axons.

Myelin is a specialized membrane which helps insulate the axon to make neural impulses

travel faster.

Glial cells in the central nervous system, are called oligodendrocytes, and glial cells

in the peripheral nervous system are called Schwann cells.

Now the myelin is composed of certain fats, and the primary fat is called galactocerebroside.

Galactocerebroside is also used to make another fat found in myelin called cerebroside sulfatide.

Over time, these fats are broken down by enzymes found within the lysosomes and peroxisomes

of the glial cells.

One enzyme that's found in the lysosome is galactosylceramidase, which is encoded

by the GALC gene.

Galactosylceramidase helps break down galactocerebroside as well as a cytotoxic metabolite called psychosine,

which is a by-product of myelin production.

Another enzyme that's in the lysosome is cerebroside-sulfatase, which is encoded by

the arylsulfatase A gene, and helps break down cerebroside sulfatide.

An enzyme in the peroxisome is adrenoleukodystrophy, which is encoded by the ABCD1 gene, and helps

break down very long chain fatty acids.

Most leukodystrophies are caused by genetic mutations and follow an autosomal recessive

inheritance patterns, but some like Adrenoleukodystrophy are X-linked recessive.

Let's go through three of the most common ones.

First off, there's Krabbe disease, named after the Danish neurologist Knud Krabbe,

and it originates from a mutation in the GALC gene, which results in a shortage of galactosylceramidase.

That leads to a buildup of galactocerebroside and psychosine, which damages the glial cells

in the central and peripheral nervous system.

Over time, dysmyelination occurs as the glial cells are no longer able to produce myelin.

Special macrophages called globoid cells move in to clear out the damaged glial cells, and

these globoid cells are a classic finding in Krabbe disease.

Typically, in Krabbe disease, symptoms begin in infancy.

It can lead to feeding difficulties, stiffness, seizures, muscle weakness, deafness, and blindness.

Next up is metachromatic leukodystrophy, which is caused by a mutation in the arylsulfatase

A gene, and results in a shortage of cerebroside-sulfatase.

That leads to a buildup of cerebroside sulfatide, which damages the glial cells in the central

and peripheral nervous system.

Over time, dysmyelination occurs as the glial cells are no longer able to produce myelin.

In metachromatic leukodystrophy, symptoms vary by the age of onset.

The late infantile form starts in children between age 1 and 2, and causes children to

have severe muscle weakness, and causes difficulty walking, running, and climbing.

Over time it progresses to causing feeding difficulties, seizures, dementia, and blindness.

If left untreated, it can cause death.

The juvenile form starts in children between age 3 and 10, and usually begins with a subtle

cognitive decline like having difficulty in school, but then causes the same symptoms

as infantile metachromatic dystrophy, including causing death.

Finally, the adult form begins in adulthood and can manifest as a psychiatric disorder

or progressive dementia.

Finally, there's adrenoleukodystrophy, which is cause by a mutation in the ABCD1 gene,

results in a shortage of adrenoleukodystrophy protein.

That leads to a buildup of very long chain fatty acids, which start to really build up

in the adrenal glands and the brain.

These very long chain fatty acids trigger an inflammatory response, which damages the

glial cells in the central and peripheral nervous system.

Like the other leukodystrophies, this leads to symptoms like feeding difficulties, stiffness,

seizures, muscle weakness, deafness, and blindness.

The fatty acids also collect inside the adrenal glands, causing it to secrete less hormones

like cortisol, and causes symptoms of Addison's disease like vomiting, weight loss, and skin

changes.

Diagnosis of leukodystrophies is done with an MRI that can help visualize degeneration

of white matter.

For metachromatic leukodystrophy, an arylsulfatase-A enzyme blood test in conjunction with a urinary

sulfatide test can be done.

In adrenoleukodystrophy, blood levels of very long chain fatty acids can be obtained.

Finally, genetic testing can help confirm the diagnosis.

Treatment of leukodystrophy starts with dietary changes to ensure that individuals avoid lipids

that they cannot metabolize.

In addition, physical therapy may be helpful for motor difficulties.

Finally, symptoms like seizures can be managed with antiepileptic medications.

Okay - so to recap, leukodystrophy is a dysmyelinating disease of the central and peripheral nervous

system caused by genetic mutations in enzymes necessary for myelin production.

The most common types are metachromatic leukodystrophy, Krabbe disease, and adrenoleukodystrophy.

Symptoms are due to neurodegeneration, like decreased motor function, muscular rigidity,

and later, blindness and hearing loss.

For more infomation >> Leukodystrophy - causes, symptoms, diagnosis, treatment, pathology - Duration: 8:05.

-------------------------------------------

How To Remove Acne Scars From Face At Home | Acne Scar Treatment - Remedies One - Duration: 3:12.

remember that because these are natural

treatments it might take a while to see

results but it will help your skin

regenerate and reduce the appearance of

scars today's video will discuss natural

solutions to reduce scars before you

watch this video please take a moment to

subscribe our youtube channel by

clicking the subscribe button then tap

the bell icon so you will be the first

to know when we post new videos daily

scars are an unsightly blemish that most

people want to get rid of or at least

improve aside from expensive treatments

there are some natural solutions that

can allow you to reduce their appearance

and restore healthy skin little by

little one

reduce scars with lemon lemons are rich

in alpha hydroxy acids which help remove

dead skin cells in a manner or much like

bleach something as simple as lemon

juice can reduce the appearance of scars

and even erase them ingredients the

juice of one lemon what should you do

one for this to work you need to first

thoroughly clean your skin to soak a

piece of cotton in the lemon juice and

apply it to the affected area 3 leave it

on for about 10 minutes and then rinse

for remember that if you're going to be

outside afterwards be sure to use

sunscreen too honey

honey can also help eliminate scars this

product stimulates the regeneration of

tissues and is very effective for the

treatment of wounds you can mix it with

baking soda for the best results

ingredients 1 tablespoon of honey 25

grams 1 tablespoon of baking soda 10

grams what should you do 1 for this to

be effective mix equal parts honey in

baking soda 2 once you have a

homogeneous mixture apply it to the area

with scarring using a gentle massage for

3 to 5 minutes 3 after that time place a

warm cloth over the area

or wait until the cloth cools and rinse

three onion onions can also be very

effective when it comes to treating his

car this vegetable contains

anti-inflammatory properties that

inhibit the production of collagen which

causes discoloration of the scars onion

extract is available in gel or cream

form which you can apply on a regular

basis for blemish free skin for tea tree

essential oil tea tree essential oil has

antibacterial properties that help

gradually reduce surgical and acne scars

what should you do mix a few drops of

essential tea tree oil with water and

apply it to the affected areas using a

little cotton which method do you like

to reduce scars let me know in our

comment section below if you liked this

video give it a thumbs up and share with

your friends for more daily tips

subscribe to our channel below thank you

For more infomation >> How To Remove Acne Scars From Face At Home | Acne Scar Treatment - Remedies One - Duration: 3:12.

-------------------------------------------

Nazre Bad Se Bachne ka Ilaj | Treatment of Nazar e Bad With Quranic Verses | Online Islamic Tutor - Duration: 10:41.

For more infomation >> Nazre Bad Se Bachne ka Ilaj | Treatment of Nazar e Bad With Quranic Verses | Online Islamic Tutor - Duration: 10:41.

-------------------------------------------

Welcome to the Columbus Orthodontic Center for Cosmetic Orthodontic Treatment! - Duration: 1:27.

Dr. Amin Mason: I love my job because the patients walk in wanting treatment.

They want to improve their appearance and their bite, and I feel very fulfilled providing

that service for them.

Columbus Orthodontic Center is actually the first office in downtown Columbus that provides

orthodontic services only.

Has a very modern feel, very open, high ceilings.

We're in a very historic building, in Atlas building, which is over 100 years old.

It is located on High Street, which is a very busy street in downtown Columbus.

We provide all orthodontic treatment options for all patients.

This allows patients and the doctor to choose the best option suitable for that specific

patient.

We are all digital office.

We provide all the newest technology in orthodontics.

I love our staff because they love to interact with patients, they like doing their job,

and they are very knowledgeable in what they do.

The favorite part of treatment for me is when I tell a patient that something can be done

when they thought that couldn't be done, or sometimes when I'm able to treat a patient's

bite without doing surgery when they were told they needed surgery.

We always love the challenge.

I think smile is something that people notice the first time around.

A patient with a great smile always has a better and higher confidence when they're

interacting with other individuals in the society.

For more infomation >> Welcome to the Columbus Orthodontic Center for Cosmetic Orthodontic Treatment! - Duration: 1:27.

-------------------------------------------

Adolescent Substance Use, Addiction, and Treatment: Full Video - Duration: 32:19.

Sarah Bagley: Hi, I'm doctor Sarah Bagley.

I'd like to talk to you today about the importance of addressing substance use in adolescence

and young adulthood.

Teens and young adults are wired to take risks and to experiment.

That means that teens and young adults are more likely to use drugs.

Adolescents and young adults are susceptible to boredom, to peer pressure, and so this

puts them at a higher risk of using alcohol and other drugs.

Adolescents and young adults may also be experiencing feelings of depression or anxiety or potentially

bullying at school, and those are some other reasons that they may decide to experiment

with alcohol and other drugs.

Well experimentation with drug and alcohol use during adolescence and young adulthood

doesn't necessarily lead to addiction.

We know that most people who develop an addiction later on started to use substances before

they were 18 years old.

Even for those adolescents and young adults who do not develop addiction, there's still

risks associated with using substances such as engaging in unsafe sex practices, getting

in motor vehicle accidents, and being vulnerable to other kinds of injuries.

Alcohol and marijuana are the most commonly used substances by adolescents.

According to Monitoring the Future, a national survey conducted every year with high school

students, we know that about 55% of all 12th graders have used alcohol in the last year

and about 36% of all 12th graders have used marijuana in the last year.

Importantly, although there is a high prevalence of alcohol and marijuana use in teenagers,

we also know that these rates are the lowest that they have been in years.

And that's really encouraging news.

It means that the prevention programs that have been implemented over the past decade

or so are making a real difference.

We also know that it means that when we're talking to teens who may say to us, "It feels

like everyone is using," we can actually use data and statistics to tell them that not

all of their friends are drinking and not all of their friends are smoking marijuana.

Adolescence is a critical time for brain development and we know that addiction is a brain disease.

All drugs work a little bit differently, but there's a similarity.

They all increase the amount of dopamine in our brain, and dopamine is the chemical that

affects our reward system and makes us feel good.

It's normal to want to feel good.

So our dopamine may increase if we eat or we do something that's enjoyable.

It also increases if we use a drug or use alcohol.

The adolescent brain, which is immature and is seeking sensations, responds really positively

when the dopamine increases in their brain, and that adolescent is going to seek to repeat

that experience and over time those repeated exposures can lead to addiction.

There's certain factors that we consider when treating adolescents and young adults who

have substance use disorder.

We're trying to prevent the downstream effects of addiction and development of other chronic

medical problems associated with addiction, and we have good treatment.

So we know that if we intervene early, we engage adolescents and young adults in treatment,

we can prevent those long-term effects.

It's also important because it allows us to intervene and try to prevent any of the short-term

effects like unwanted pregnancy, transmission of sexually transmitted infections, or other

infections that might be associated with injection drug use.

It's important to understand that many adolescents and young adults who have substance use disorder

also may have other mental health diagnoses like anxiety or depression.

When we treat adolescents and young adults we have to consider the other diagnosis they

may have and want to make sure that we're treating both of those conditions together.

We know that adolescents and young adults who are treated for both their substance use

and their mental health disorders do better.

That means that they're able to go back to school, go back to jobs, and rejoin the lives

that they want to have.

Addiction is a highly stigmatized disease, and we even find that some of the treatments

that we use for addiction are also stigmatized.

Some of the stigma is associated with having an addiction and a general perception in the

public that this is, the addiction is the result of lack of willpower, poor choices,

or just bad habits that people have.

We often find too that there's stigma associated with the medications we use to treat an opioid

use disorder.

So we hear in the community sometimes that we're just substituting one drug for another.

One really easy way that we can all try to reduce the stigma associated with addiction

is to change the language that we use.

For example, using person first language, so trying to get rid of terms like addict

or alcoholic or terms like abuse, and instead say person with a substance use disorder or

person with an alcoholic use disorder or someone who is misusing substances.

Another way that we can reduce the stigma associated with addiction is to use medically

accurate terminology.

We know that addiction is a brain disease, it's a chronic illness, and so that we should

use terms like we do when talking about asthma or COPD or diabetes or other chronic medical

illnesses when talking about patients who have addiction.

For a really long time people who had substance use or alcohol use disorders were viewed as

being weak, that they had a habit that they couldn't get rid of, and that they just needed

to have the willpower in order to overcome what was going on and change their lives.

Over the last couple of decades we have had definitive research showing that in fact addiction

is a brain disease, it's a chronic relapsing disease, and that people need more than just

willpower in order to recover from their alcohol or substance use disorder.

In our program we handle this a couple of ways.

One is just being really upfront with our patients and telling them that we recognize

that this is a stigmatizing disease and we recognize that there might have been a lot

of places in their life that they have been where they felt judged.

And just by showing them that we understand that, patients often will literally just relax

in our offices and we can see that they feel like they're in a safe place.

We know both through research and from talking to patients that because of the stigma associated

with addiction, people are less likely to seek treatment or ask for help.

That's because they're worried about being judged or they maybe have family members who

are concerned about what it's going to mean if they find themselves in treatment for an

alcohol or substance abuse disorder.

If you have any questions about what the right terms are to use, or what stigma might mean

when we're talking about stigma associated with addiction, feel free to ask.

People who are experts or people who maybe have a substance use disorder would be happy

to talk to you about that, and the humility you show by asking expresses the empathy that

you have for patients who have substance use disorder.

The first step to identify substance use in an adolescent is to recognize some of the

warning signs as early as possible.

Parents and all adults who interact with adolescents and young adults should be aware of some of

the warning signs of substance use.

These might include changes in behavior like becoming more withdrawn, or seeming more depressed,

changes in grades, maybe dropping out of school or losing a job, changes in friends, becoming

less interested in activities or in sports that the adolescent or young adult used to

be excited about.

Some other signs that substance use may be a problem for an adolescent or a young adult

is not been able to stop using when after having a conversation with a parent or other

adult about stopping use, trying to hide alcohol or substance use, or becoming really defensive

in conversations around substance use.

These signs can be really subtle, and it's important to recognize that some of these

signs might be symptoms of having a mental health diagnosis like depression or anxiety.

And so it's really important that parents or other adults involved in an adolescent

or young adult's life is able to have an open and honest conversation about what's going

on and ensure that that adolescent and young adult have access to an assessment to figure

out whether or not is substance use or other mental health problems that may be causing

their symptoms.

It's also important to realize that a lot of these signs can be subtle and sometimes

they don't exist at all or may not show up until later on when substance use has become

more problematic and parents shouldn't feel guilty if they missed these signs in their

adolescent.

Physicians such as primary care providers are trained to ask adolescents in a confidential

way at their annual exam about substance use, and parents can ask their primary care providers

to make sure that that assessment is happening every year.

When a substance use disorder is identified in an adolescent or in a young adult, it's

important that the first message that that teen or young adult is receiving is that no

matter what happens, the parent or the other caregiver is going to be there for them.

This can be a really difficult time and the teen or young adult may feel really alienated.

And if they feel like they can't have an open and honest conversation, then it's going to

be really difficult to engage that person in any kind of treatment.

It's important then to find substance use disorder services that are appropriate for

teenagers and young adults.

A lot of the treatments available for people with substance use disorder are tailored towards

adult, and teens and young adults have different needs.

You should make sure that you look for treatment that has professionals who are trained in

taking care of teens and young adults, and you can always talk to your primary care provider

to ensure that that treatment is appropriate.

Parents should look for treatment that addresses both the physical and the mental health needs

of their teen or their young adult.

Treatment should also include support for both the patient and also the family.

For example, at the CATALYST Clinic where I work at Boston Medical Center, we have a

team-based approach where our team is composed of physicians, social workers, nurses, recovery

coach, and so that way we're able to really wrap around our patients and make sure that

all of their needs are being addressed.

Part of support for a family whose adolescent or young adult is going through substance

use disorder treatment is helping the family realize that this isn't their fault.

A lot of the families that we meet feel guilty or they wonder whether or not they missed

any signs or symptoms of what was going on with their child.

We try to be really clear that addiction is a really complicated disease and it's easy

to miss the signs, and that the parents shouldn't feel guilty about that and moving forward

it's important to make sure that we're supporting them in figuring out how to communicate and

support their child struggling with a substance use disorder.

We offer our services in a primary care clinic which allow us to address both the physical

and the mental health needs of all of our patients and their families.

We offer primary care.

We offer assessment and diagnosis of substance use disorder.

We treat patients with medications for alcohol and opioid use disorder.

We offer our patients therapy and recovery support.

In addition, we screen our patients for HIV and hepatitis C and link them to treatment

as needed and also link them to psychiatry care if indicated.

Some additional components of the substance use disorder treatment that we offer at CATALYST

may include monitoring for drug use with urine drug testing, offering overdose education

and naloxone for patients and their families, and also offering recovery support through

outreach services.

We have found that a lot of our patients have barriers that are related to social issues

such as housing and transportation, and we recognize that it's critical to address those

issues too if we want our patients to meet the recovery and have the recovery that they

want.

Substance use disorder services offered to teens and to young adults are different than

those services that are offered to older adults.

Some of the key differences are that oftentimes involvement of family is critical to the success

of a teen and a young adult with a substance use disorder.

It's also important that we recognize that peers play a major role in the lives of teens

and young adults, and for some teens and young adults, they may rely on their peers more

than their family.

Part of the work that we have to do is to help them find sober networks of friends so

that they can find ways to enjoy activities without substances.

Another component of treatment that's different is that some of these teens and young adults

may have dropped out of school are having trouble finishing school.

In order for them to go on, to get the job that they want, and again, have the lives

that they want and the full recovery, means that our services have to address getting

them back into school or helping them finish school or finding employment.

An additional key difference between treating adolescents and young adults compared to older

adults is that we have to sometimes go into the community to find them where they are.

Older adults may be more likely to actually come to a clinic or come to a program to receive

treatment.

But teens and young adults have a lot of ambivalence.

They may not want to go to the doctor's office.

So part of the work we do is going to find them where they are, which might be in schools,

might be in community centers, or in other places where teens and young adults congregate.

We've all heard a lot about the increase in opioid related overdose deaths in the United

States.

But you may be wondering, "How do those relate to adolescents?"

Well, there's some good news and some bad news.

Some of the good news is that prescription opioid use among adolescents continues to

decrease, and we know that from the National Survey on Drug Use and Health and the Monitoring

The Future study, both surveys that are conducted among youth every year.

However, there was a study that came out in 2016 that looked at opioid related poisonings

in youth during the time period where we've seen opioid deaths rise in adults.

In that study, there was 176% increase in opioid related admissions for poisonings in

15 to 19 year-olds.

There was also a data brief released by the National Center on Health Statistics in the

middle of August 2017 that showed a significant increase in overdose deaths from opioids among

teenagers in the last couple of years.

Then you may wonder, "Well, what's going on with young adults?"

We know that young adults use substances at higher rates than other age groups and that

holds true for opioids as well.

From 2002 to 2013 there was 108% increase in past year heroin use in 18 to 25 year-olds.

However, we also know that opioid related overdose deaths are lower in emerging adults

or young adults compared to older age groups.

Driving home the point that intervening early with this group is really important so that

we try to prevent those deaths later on in life.

Teens and young adults use opioids for a lot of the same reasons that they may decide to

try other substances.

It might be because it's sensations seeking and they like the high that they get when

they try a pill.

It might be because they're feeling depressed or hopeless, and taking the opioid relieves

that feeling that they have.

It may also be because they're bored and it's what their friends are doing and so that's

why they decide to do it.

It can be difficult to engage an adolescent or a young adult in treatment, and that might

even mean it can be difficult for them to remember to come in.

There are a couple of things that we do in our program that we think increases the likelihood

that our patients will show up for their appointments and for their care.

One of the things that we do is we do a lot of reminder calls.

We'll do multiple reminder calls.

We also will tell our patients that if they're having trouble with transportation, we'll

help subsidize that, and so we might give them a public pass for public transportation

or try to help pay some of their parking fees as well.

In addition, for patients who might not have access to food, we'll try to make sure that

they have access to snacks or other meals when they come to the visit.

And for some patients who may be trying to visit family who are far away, we may even

pay for a bus ticket.

All of these things we feel like are important to demonstrate to our patients that their

engagement with us is important and that we also recognize that they are more than just

their disease and have other things going on in their lives, and really showing them

that we recognize that unless we're addressing those it's going to be hard for them to show

up.

Treatment for opioid use disorder in adolescents and young adults really falls into two buckets.

One is behavioral health treatment and that can include different kinds of manualized

but evidence based therapy like cognitive behavioral therapy, motivational enhancement

therapy, and the adolescent community reinforcement approach among others.

Importantly, any kind of behavioral health treatment that's offered to adolescents and

young adults should also involve the family and should include family therapy and potentially

support for families like mutual help groups.

Best practice currently calls for medication to be added to behavioral therapy for patients

who have opioid use disorder.

What I often tell my patients is that the medication is going to help calm their brain

down so they're able to focus on the recovery, but that it's going to be really hard to talk

about their depression or anxiety or think about relapse prevention and how they can

not go out and use again if they're having a lot of cravings.

And that's what medication can do.

But that it's really important the patients also engage in behavioral health treatment

because it takes a lot of work to get sober and getting extra help from trained professionals

is going to lead to better success for them.

With adolescents and young adults it's critical to intervene early because we're trying to

prevent the downstream effects of longstanding addiction.

That means that we're trying to prevent transmission of HIV, of hepatitis C, of complications from

injection like skin infections or infections in the blood stream or the heart, and we know

that some of these medications can help prevent those diseases from occurring.

We're also trying to ensure that adolescents and young adults are able to stay engaged

with school or work, with their other goals that they have with their life and that medications

can help them to do that.

Although there have been fewer studies conducted in adolescents and young adults compared to

older adults, the evidence that we do have shows that treatment with these medications

does work.

Importantly, a statement from the American Academy of Pediatrics came out in 2016 and

recommended that providers offer medication treatment to adolescents and young adults

with opioid addiction.

This statement from the American Academy of Pediatrics was the first statement of its

kind from a pediatric organization recommending treatment with medication for opioid use disorder

in adolescents and young adults and represented a real paradigm shift in how we're thinking

about caring for this age group with opioid use disorder.

Oftentimes we hear from patients and families and sometimes other treatment providers that

medication should be used as a last resort.

However, when we think about other chronic illnesses like asthma or diabetes we would

never wait until someone hit bottom before starting treatment.

We think that it's important to offer medication for opioid use disorder to adolescents and

young adults as soon as we have a diagnosis.

There are three medications that we use to treat opioid use disorder in adolescents and

young adults.

Two of the medications, methadone and buprenorphine, work by controlling withdrawal symptoms or

treating the withdrawal symptoms someone may have after stopping opioid use.

They also help control cravings that people have for using the drug.

For example, if someone is spending a lot of time sort of thinking about how they're

going to go get heroine, taking methadone or taking buprenorphine helps take away some

of those thoughts.

Methadone and buprenorphine also go to that opioid receptor and sit on it really tightly.

So if someone tries to use heroin or another opioid while they're taking their medication,

that heroin or other opioid isn't able to cause a high.

Naltrexone works a little bit differently.

Naltrexone goes to the opioid receptor and sits on it and blocks any other opioid from

coming and causing a high.

Naltrexone doesn't necessarily help with cravings with all patients but it helps for some.

You may have heard of naloxone or NARCAN.

This is the medication that's used to reverse an acute opioid overdose and is being distributed

to people who use drugs and also to family members and anyone else who may be around

someone who's at risk for an overdose.

Naloxone can be given different ways.

It can be given as a spray in the nose and can also be given intramuscularly, and once

administered it can reverse an opioid overdose and save a life.

In addition to medication and behavioral healthcare it's important to recognize that there may

be other barriers to care that teens and young adults may be facing, and these are related

to social issues they might be having.

A lot of our patients are faced with homelessness or housing insecurity, might have a hard time

accessing healthy food, might also have hard time with transportation and being able to

get around to their appointments or to school or to their jobs.

We recognize that it's going to be really hard for them to do all they need to do to

get sober if we're not also addressing their needs.

The CATALYST program is a multidisciplinary program at Boston Medical Center that developed

because Boston Medical Center has this long history of taking care of adults with substance

use disorder and primary care and does an excellent job in doing that.

They care for patients in primary care and the emergency department and in OB and obstetrics.

There was really a gap though in terms of the services that were being offered to adolescents

and young adults.

We recognize that that was actually a gap that was felt across our city.

So CATALYST was created to address the need of ongoing substance use in adolescents and

young adults.

We have a team that's composed of physicians, social workers, nurses, program manager.

We also work really closely with our child and adolescents psychiatrist.

Importantly we have added a recovery coach to our model which is a little bit different

so that individual has a background in what's called, recovery coaching and can address

patients specific needs to their recovery in addition to their social determinant.

We see patients in both the adolescent center of Boston Medical Center and also in adult

primary care.

So we're able to match our patients to sort of where they fit developmentally.

When a patient calls or a family member calls or we receive a referral for a new patient,

we set up an appointment with a physician and a social worker so we can do a first visit

and an assessment of what's going on with the patient.

We then, the following week develop a treatment plan.

We meet every week as a team to talk about what's going on with our patients and there

we'll discuss new patients and ongoing issues with existing patients.

We feel like the team base approach that we have is really important.

I think another really important part of our model is that there we try to have basically

no hierarchy and everyone's really contributing to the treatment plan in an equal way.

We recognize that addiction is a complicated disease and although it's a brain disease

there are a lot of other things going on in that person's life that need to be addressed.

That each team member's specific training is there to be able to address those different

issues.

We started seeing patients in the CATALYST program in May of 2016.

At this point we are putting together a database so that we can start to track out outcomes

because we recognize that there's so few programs like this in the United States that it's important

that we figure out what we're doing well but also different things that we need to do to

improve so that we can share our models with other programs.

I'm gonna talk about some of the biggest challenges that we face in treating teens and young adults

with substance use disorder.

The first is ambivalence.

So the teenage years and young adulthood is really characterized by ambivalence and difficulty

in making decisions.

So we find that it can be very difficult to engage our patients and have them agree with

us that they may need treatment for their substance use disorder and this can be a huge

barrier to care.

Another significant challenge that we face everyday in our work is the stigma associated

with both the disease of addiction and the medications that we're using to treat addiction.

This can be ... make it difficult to get patients to come into care for the first place or it

can make patients and families resistant to accepting the kind of treatment that when

we wanna offer them.

The third challenge that we see commonly and this is particular to my practice are issues

around social determinant of health.

So such as housing and employment, school issues, transportation, being able to pay

for bills.

We've heard from our patients and their families time and time again that if those basic needs

aren't being met, it's really hard for them to focus on their recovery.

So we do everything that we can in our program to try to address those needs, but we're an

outpatient based program and there are limited resources.

There are different ways that you can involve parents and family members and treatment for

a substance use disorder with their teen or their young adult.

We invite all parents or family members into visits and sometimes have family meetings.

This is of course done with the permission of the patient.

The patients can provide guidelines for how those visits are gonna go and what information

is gonna be shared.

But we try to explain to our patients that it's really important and it's really critical

to their success to have their families involved as much as possible.

We also provide referrals for families to mutual help groups which really means support

groups that are led by other parents and family members who have loved ones who are struggling

with addiction, or to family therapy.

In our program, we plan to start parent groups and so these are gonna be educational sessions

for parents and other family members who are affected by substance use, specifically targeted

for those who have loved ones not willing to engage in treatment.

It can be a lot to be telling a 18 or 19 year old that they have a chronic illness that

they're gonna be living with for the rest of their life.

Once they start to hear that message, they may not wanna come into clinic to receive

treatment.

What we try to do is we tell our patients from the start that we're there for them no

matter what.

We try to identify other things that are going on in their lives that might be challenging.

So issues around school or a job or with transportation and sometimes by addressing some of the other

challenges that they have going on in their life we're able to then engage them in treatment

for their substance use.

When caveat to this is that when we're taking care of patients who are less than 18 years

old, sometimes other challenges come up and because of their age.

So for example, if we have a patient who is 16 and we know that that person may is injecting

heroine or other opioids and is really at acute risk, then sometimes we may have to

break confidentiality and engage other agencies to assure the safety of that child.

It's really important when working with teens and young adults who have substance use disorder

or who are using substances, to spend a lot of time building trust and building rapport.

A lot of these teens and young adults might be coming from families where there are issues

around communication or they might have a lot of other experiences in their life where

their trust was broken.

So spending some concentrated time, really explaining, reassuring and demonstrating through

having open doors, calling back quickly, having other members of the team sort of address

their other social needs, can make a real difference in terms of engaging with them.

I think it's also important to recognize with teens and young adults because they may be

ambivalent.

That they might not show up initially to an appointment or they might stay engaged and

then drop out of care.

But we have also found that by giving them this message that we're there no matter what.

That a lot of our patients, even if it's been a couple of months will come back to us and

they will tell us and their parents will tell us, that they felt that it was important to

come back to us because we were safe, we had told them that no matter what was going on,

this was a place that they could come to.

For more infomation >> Adolescent Substance Use, Addiction, and Treatment: Full Video - Duration: 32:19.

-------------------------------------------

Baystate Health presented $25K check by CVS to support opiate treatment program - Duration: 0:27.

For more infomation >> Baystate Health presented $25K check by CVS to support opiate treatment program - Duration: 0:27.

-------------------------------------------

Mascarilla hidratante The Treatment Lotion | La Mer - Duration: 0:31.

For more infomation >> Mascarilla hidratante The Treatment Lotion | La Mer - Duration: 0:31.

-------------------------------------------

Adolescent Substance Use, Addiction, and Treatment: Segment 6 - Duration: 9:29.

The CATALYST program is a multidisciplinary program at Boston Medical Center that developed

because Boston Medical Center has this long history of taking care of adults with substance

use disorder and primary care and does an excellent job in doing that.

They care for patients in primary care and the emergency department and in OB and obstetrics.

There was really a gap though in terms of the services that were being offered to adolescents

and young adults.

We recognize that that was actually a gap that was felt across our city.

So CATALYST was created to address the need of ongoing substance use in adolescents and

young adults.

We have a team that's composed of physicians, social workers, nurses, program manager.

We also work really closely with our child and adolescents psychiatrist.

Importantly we have added a recovery coach to our model which is a little bit different

so that individual has a background in what's called, recovery coaching and can address

patients specific needs to their recovery in addition to their social determinant.

We see patients in both the adolescent center of Boston Medical Center and also in adult

primary care.

So we're able to match our patients to sort of where they fit developmentally.

When a patient calls or a family member calls or we receive a referral for a new patient,

we set up an appointment with a physician and a social worker so we can do a first visit

and an assessment of what's going on with the patient.

We then, the following week develop a treatment plan.

We meet every week as a team to talk about what's going on with our patients and there

we'll discuss new patients and ongoing issues with existing patients.

We feel like the team base approach that we have is really important.

I think another really important part of our model is that there we try to have basically

no hierarchy and everyone's really contributing to the treatment plan in an equal way.

We recognize that addiction is a complicated disease and although it's a brain disease

there are a lot of other things going on in that person's life that need to be addressed.

That each team member's specific training is there to be able to address those different

issues.

We started seeing patients in the CATALYST program in May of 2016.

At this point we are putting together a database so that we can start to track out outcomes

because we recognize that there's so few programs like this in the United States that it's important

that we figure out what we're doing well but also different things that we need to do to

improve so that we can share our models with other programs.

I'm gonna talk about some of the biggest challenges that we face in treating teens and young adults

with substance use disorder.

The first is ambivalence.

So the teenage years and young adulthood is really characterized by ambivalence and difficulty

in making decisions.

So we find that it can be very difficult to engage our patients and have them agree with

us that they may need treatment for their substance use disorder and this can be a huge

barrier to care.

Another significant challenge that we face everyday in our work is the stigma associated

with both the disease of addiction and the medications that we're using to treat addiction.

This can be ... make it difficult to get patients to come into care for the first place or it

can make patients and families resistant to accepting the kind of treatment that when

we wanna offer them.

The third challenge that we see commonly and this is particular to my practice are issues

around social determinant of health.

So such as housing and employment, school issues, transportation, being able to pay

for bills.

We've heard from our patients and their families time and time again that if those basic needs

aren't being met, it's really hard for them to focus on their recovery.

So we do everything that we can in our program to try to address those needs, but we're an

outpatient based program and there are limited resources.

There are different ways that you can involve parents and family members and treatment for

a substance use disorder with their teen or their young adult.

We invite all parents or family members into visits and sometimes have family meetings.

This is of course done with the permission of the patient.

The patients can provide guidelines for how those visits are gonna go and what information

is gonna be shared.

But we try to explain to our patients that it's really important and it's really critical

to their success to have their families involved as much as possible.

We also provide referrals for families to mutual help groups which really means support

groups that are led by other parents and family members who have loved ones who are struggling

with addiction, or to family therapy.

In our program, we plan to start parent groups and so these are gonna be educational sessions

for parents and other family members who are affected by substance use, specifically targeted

for those who have loved ones not willing to engage in treatment.

It can be a lot to be telling a 18 or 19 year old that they have a chronic illness that

they're gonna be living with for the rest of their life.

Once they start to hear that message, they may not wanna come into clinic to receive

treatment.

What we try to do is we tell our patients from the start that we're there for them no

matter what.

We try to identify other things that are going on in their lives that might be challenging.

So issues around school or a job or with transportation and sometimes by addressing some of the other

challenges that they have going on in their life we're able to then engage them in treatment

for their substance use.

When caveat to this is that when we're taking care of patients who are less than 18 years

old, sometimes other challenges come up and because of their age.

So for example, if we have a patient who is 16 and we know that that person may is injecting

heroine or other opioids and is really at acute risk, then sometimes we may have to

break confidentiality and engage other agencies to assure the safety of that child.

It's really important when working with teens and young adults who have substance use disorder

or who are using substances, to spend a lot of time building trust and building rapport.

A lot of these teens and young adults might be coming from families where there are issues

around communication or they might have a lot of other experiences in their life where

their trust was broken.

So spending some concentrated time, really explaining, reassuring and demonstrating through

having open doors, calling back quickly, having other members of the team sort of address

their other social needs, can make a real difference in terms of engaging with them.

I think it's also important to recognize with teens and young adults because they may be

ambivalent.

That they might not show up initially to an appointment or they might stay engaged and

then drop out of care.

But we have also found that by giving them this message that we're there no matter what.

That a lot of our patients, even if it's been a couple of months will come back to us and

they will tell us and their parents will tell us, that they felt that it was important to

come back to us because we were safe, we had told them that no matter what was going on,

this was a place that they could come to.

For more infomation >> Adolescent Substance Use, Addiction, and Treatment: Segment 6 - Duration: 9:29.

-------------------------------------------

5 Natural Remedies for Joint And Knee Pain l knee pain treatment at home Naturally - Duration: 3:38.

Apple Cider Vinegar The alkalizing effect of apple cider vinegar

softens mineral build-ups and unhealthy toxins within your knee joint.

It also supports to restore joint lubricants to lessen pain and improve mobility.

Apple Cider Vinegar is an excellent source for decreasing your knee joint pain.

You can mix apple cider vinegar with water and drink it daily before going to bed.

You can also add some amount of it in your water bathtub and drown knee for 20-25 minutes.

Another way to use apple cider vinegar is to blend it with coconut oil and apply on

the affected area of the knee Ginger

The presence of compounds like gingerol makes it a potent anti-inflammatory and analgesic

treatment.

For health issues like arthritis, muscle strain or injury, ginger is a powerful remedy as

it helps in alleviating the pain.

Add a little piece of fresh ginger to a cup of water and boil it.

You can also add honey and lemon juice for better taste.

You can also have two to three cups of this ginger tea daily until the pain is gone.

Massage the affected knee area with ginger oil twice a day for better results.

Turmeric The chemical compound present in turmeric

is called curcumin.

It has anti-inflammatory as well as antioxidant properties that help you to reduce pain.

It alleviates signs of knee joint pain and inflammation.

Add ginger and turmeric in water and boil for 12-15 minutes.

Add honey or lemon juice for taste.

You can also mix turmeric with milk and add some sugar to sweeten it.

Another option is to take 250 to 500 mg turmeric capsules three times a day.

Lemon Lemon has multiple health advantages.

The anti-inflammatory traits in lemons aid to decrease inflammation, pain, and swelling

that guide knee pain.

The citric acid in lemon toils as a moderator for uric acid crystals, which is the cause

of some types of arthritis.

All you need to do is put tiny slices of lemon in a cotton fabric and soak it in warm sesame

oil.

Place the cloth on the affected knee for 5 to 10 minutes.

Do this twice daily until the pain is gone entirely.

Apart from this, you can also drink lemon tea, mix lemon with water and have it on a

daily basis for better metabolism.

Cayenne Pepper Presence of capsaicin in the cayenne pepper

(lal mirch) is an excellent antidote for treating knee joint pain.

It acts as a natural pain reliever because of its anti-inflammatory and analgesic properties.

You can prepare a mixture by adding two tablespoons of cayenne pepper powder in half cup of warm

olive oil.

Applying this paste on the injured area twice daily for at least one week will give better

results.

For more infomation >> 5 Natural Remedies for Joint And Knee Pain l knee pain treatment at home Naturally - Duration: 3:38.

-------------------------------------------

Adolescent Substance Use, Addiction, and Treatment: Segment 1 - Duration: 4:50.

Hi, I'm Dr. Sarah Bagley.

I'd like to talk to you today about the importance of addressing substance use in adolescence

and adulthood.

Teens and young adults are wired to take risks and to experiment.

That means that teens and young adults are more likely to use drugs.

Adolescents and young adults are susceptible to boredom, to peer pressure.

And this puts them at a higher risk of using alcohol and other drugs.

Adolescents and young adults may also be experiencing feelings of depression or anxiety or potentially

bullying at school.

And those are some reasons that they may decide to experiment with alcohol and other drugs.

While experimentation with drug and alcohol use during adolescence and young adulthood

doesn't necessarily lead to addiction, we know that most people who develop an addiction

later on started to use substances before they were 18 years old.

Even for those adolescents and young adults who do not develop addiction there is still

risks associated with using substances, such as engaging in unsafe sex practices, getting

in motor vehicle accidents, and being vulnerable to other kinds of injuries.

Alcohol and marijuana are the most commonly used substances by adolescents.

According to Monitoring the Future, a national survey conducted every year with high school

students, we know that about 55% of all 12th graders have used alcohol in the last year

and about 36% of all 12th graders have used marijuana in the last year.

Importantly, although there is a high prevalence of alcohol and marijuana use in teenagers,

we also know that these rates are the lowest that they have been in years.

And that's really encouraging news.

It means that the prevention programs that we have been implemented over the past decade

or so are making a real difference.

We also know that it means that when we're talking to teens who may say to us, "It feels

like everyone is using," we can actually use data and statistics to tell them that not

all of their friends are drinking and not all of their friends are smoking marijuana.

Adolescence is a critical time for brain development and we know that addiction is a brain disease.

All drugs work a little bit differently, but there's a similarity.

They all increase the amount of dopamine in our brain and dopamine is the chemical that

affects our reward system and makes us feel good.

It's normal to want to feel good and so our dopamine may increase if we eat or we do something

that's enjoyable.

It also increases if we use a drug or use alcohol.

The adolescent brain, which is immature and is seeking sensations, responds really positively

when the dopamine increases in their brain and they're at ... that adolescent is going

to seek to repeat that experience and over time those repeated exposures can lead to

addiction.

There are certain factors that we consider when treating adolescents and young adults

who have substance use disorder.

We're trying to prevent the downstream effects of addiction and development of other chronic

medical problems associated with addiction and we have good treatments.

And we know that if we intervene early, we engage adolescents and young adults in treatment,

we can prevent those long-term effects.

It's also important because it allows us to intervene and try to prevent any of the short-term

effects, like unwanted pregnancy, transmission of sexually transmitted infections, or other

infections that might be associated with injection drug use.

It's important to understand that many adolescents and young adults who had substance use disorder

also may have other mental health diagnoses, like anxiety or depression.

When we treat adolescents and young adults, we have to consider the other diagnoses they

may have and want to make sure that we're treating both of those conditions together.

We know that adolescents and young adults who are treated for both their substance abuse

and their mental health disorders do better.

That means that they're able to go back to school, go back to jobs, and rejoin the lives

that they want to have.

For more infomation >> Adolescent Substance Use, Addiction, and Treatment: Segment 1 - Duration: 4:50.

-------------------------------------------

Australia planning to single Aphiwe Dyantyi out for special treatment - Duration: 4:14.

Australia planning to single Aphiwe Dyantyi out for special treatment

Australia planning to single Aphiwe Dyantyi out for special treatment.

  Hot-stepping Springbok speedster Aphiwe Dyantyi will be a marked man when he faces the Wallabies in Port Elizabeth on Saturday‚ Australian wing Marika Koroibete said.

Dyantyi was one of the heroes when the Boks shocked the All Blacks and he can expect to be singled out for special treatment at Nelson Mandela Bay Stadium here in Port Elizabeth.

With a sellout 46‚000 crowd urging him forward on attack‚ Dyantyi will test a shaky Wallaby defence as the Boks hunt back-to-back Rugby Championship wins.

His two tries against the All Blacks earned him the man of the match award in Wellington‚ and his blistering pace caught the eye of Koroibete.

"Dyantyi has been impressive‚" Koroibete told Rugby Australia.

"This week we are going to work on something to stop him from scoring tries.

He's a really exciting player for the Springboks.

"I played my first Test start here in South Africa and since then I have been in the starting line-up and playing more with the boys.

"It's given me confidence‚ knowing each other's game.

The last couple of weeks have been tough but I'm going to play my best and do my best for the team." It is 12 months since Koroibete put his name in lights with two tries against the Boks on his Australian debut.

Koroibete's try scoring ability coupled with his strong defence‚ persuaded Australian coach Michael Cheika to hand him 13 straight Test starts in the year since his Bloemfontein debut.

Australian forward Ned Hanigan is expecting the Bok side that lines up this weekend to play more like they did in Wellington than the losing effort in Brisbane when the sides met earlier in the competition.

"They'll just do exactly what they did leading into that All Blacks Test‚" he said.

"Beating that side is a hell of an achievement over there.

"They'll know their processes leading into that week were right‚ so they'll make sure they keep nailing that and we've obviously got to make a few changes.

The Wallabies slumped to their lowest world ranking (seventh) after their defeat to Argentina.

Since their arrival in South Africa there has been much soul-searching about what can be done with a troubled team that has managed just two wins in their last nine Tests.

Their alarming slide was reinforced by the 23-19 upset win by Argentina on the Gold Coast on Saturday.

It was the first victory for the Pumas on Australian soil in 35 years‚ which left the Wallabies last on the four-team Rugby Championship log.

For more infomation >> Australia planning to single Aphiwe Dyantyi out for special treatment - Duration: 4:14.

-------------------------------------------

Adolescent Substance Use, Addiction, and Treatment: Segment 2 - Duration: 3:36.

Addiction is a highly stigmatized disease and we even find that some of the treatments

that we use for addiction are also stigmatized.

Some of the stigmas associated with having an addiction and a general perception in the

public, that addiction is the result of a lack of will power, poor choices, or just

bad habits that people have.

We often find too, that there's stigma associated with the medications we use to treat an opioid

use disorder.

So we hear in the community some times that we're just substituting one drug for another.

One really easy way that we can all try to reduce the stigma associated with addiction

is to change the language that we use.

So for example, using person first language, so not trying to get rid of terms like addict

or alcoholic or terms like abuse and instead say person with a substance use disorder,

or person with an alcohol use disorder, or someone who is misusing substances.

Another way that we can reduce the stigma associated with addiction is to use medically

accurate terminology.

We know that addiction is a brain disease.

It's a chronic illness and so we should use terms like we do when talking about asthma,

or COPD or diabetes or other chronic medical illnesses when talking about patients who

have addiction.

For a really long time, people who had substance abuse or alcohol use disorders were viewed

as being weak, that they had a habit that they couldn't get rid of and that they just

needed to have the willpower in order to overcome what was going on and change there lives.

Over the last couple of decades we have had definitive research showing that in fact,

addiction is a brain disease.

It's a chronic relapsing disease and that people need more than just will power in order

to recover from the alcohol or substance use disorder.

In our program we handle this a couple of ways.

One is just being really upfront with our patients and telling them that we recognize

that this is a stigmatizing disease and we recognize that there might have been a lot

of places in there lives that they've been where they've felt judged.

Just by showing them that we understand that, patients often will literally just relax in

our offices and we can see that they feel like they're in a safe place.

We know both through research and from talking to patients that because of the stigma associated

with addiction, people are less likely to seek treatment or ask for help.

That's because they are worried about being judged or they maybe have family members who

are concerned about what it's gonna mean if they find themselves in treatment for an alcohol

or substance abuse disorder.

If you have any questions about what the right terms are to use, or what stigma might mean

when we're talking about stigma associated with addiction.

Feel free to ask people who are experts, or people who maybe have a substance abuse disorder

would be happy to talk to you about that.

The humility that show by asking expresses the empathy that you have for patients who

have substance use disorder.

For more infomation >> Adolescent Substance Use, Addiction, and Treatment: Segment 2 - Duration: 3:36.

-------------------------------------------

How To Stop Diarrhea | Loose Motion Medicine | Diarrhea Treatment - Duration: 6:38.

hi , i am Chacha Foji

I am here to

present my new new video with you guys.

This new Remedy

is just for

you guys

which is about Diarrhea, Loose motions.

You dont have to go to any doctor,

you can simply make this remedy

at home

With the Blessing of God

your diarrhea or loose motion,

which occurs usually in summer.

you even go to doctors but no results .

This homemade remedy will just cost you less then 50 Rs

Just 20 to 30 cents

With the help of God I will show you the way

to make this remedy with just few things

so you can make this remedy at your own home

and dont have to go to any Doctors

I start with the Name Of God who is very merciful

and kind.

These are

Jamun Seeds

Black Plum Seeds

There Efficacies is very good for us

These Jamuns only came once in a year

These black plum seeds only cost me 20 Rs

and this

is Brown Sugar

Which also cost 20 Rs and this

is Yogurt which also cost me 20 Rs.

This remedy i am making

is just for you guys , and it is effective

so stay tuned , keep watching for whole procedure

you have to keenly take care of every point that i will describe

With the help of God

Your diarrhea will be cured with this remedy.

Now I am crushing these black plum seeds

keep watching

how i make diarrhea treatment

keep watching

after crushing it into powder we will mix brown suger

into it after that.....

we will

mix it into YOGURT

AND MAKE ITS MILK SHAKE

This is Black plum seeds

,which i am crushing

keep watching my remedy .......

If u have any Health problem u can ask me..

Your problem solution will be ME..

you have to crush it into POWDER FORM

make it like powder

you have to crush it with mortar and pestle

Because its Efficacies can

only be stable

by this.

as you can see

black plum seeds are shaping up...

only Crush it with this pestle

If u grinf these black plum seeds

then its power

will be finished,

Now next step is, if u have constant diarrhea

take 1 table spoon of this mixture,

and add it

into grinder.

Now ADD 2 table spoons

of Brown Sugar

Now,

add little bit of

Yogurt into grinder.

add some water

water is added,

In Grinder we added Crushed Jamun

seeds

2 table spoons of Brown sugar.

a little bit of water and Yogurt.

Now Grind These Ingredients and make some thing like lassi

or Milk shake .

Now it is ready,

Just Drink It Up...

If u have Diarrhea in summer or winter,

these things which i showed u earlier ,

Crushed Jamun seeds,brown suger,yogurt and water

either your diarrhea is from winter or summer,

you have to

make it like milk shake and drink it,

i will show you how to drink this milk shake,

i am just giving you this remedy as gift,you can easily make it at home,

and dont have to go to Doctors either.

Drink it like so...

As u can see,

i drink it and mine diarrhea will be cured.

If u make this Remedy

at you own home

and after that you get any results,

Then Hit like to my Video

as well as watching

and dont forget to Subscribe

my Channel . Thank You

Không có nhận xét nào:

Đăng nhận xét