Thứ Hai, 31 tháng 12, 2018

Auto news on Youtube Jan 1 2019

Brick and mortar businesses can derive significant advantages

from gathering and analyzing data about consumer behavior

patterns.

For example, data analytics allows

retailers to increase sales per visit,

improve inventory management, and enhance experiences

by offering the products and services customers

are looking for.

I'm Stephanie Essin, and in this episode of IDC Weekly,

we take a look at Scanalytics together

with Intel and their development of a simple solution

that offers retailers precise data insights

into their consumers' behavior.

According to McKinsey and Company,

data analytics has the potential to increase net retailer

margins as much as 60%.

Data analytics allows retailers to take advantage of strategies

like market basket analysis, which

can assess what products get a boost when adjacent products go

on sale.

Scanalytics uses their Sole-Sensor intelligent floor

sensors to monitor foot traffic with remarkable accuracy

and deliver data-based insights that can improve almost

every aspect of a business.

This data is processed in the cloud

and sent to end users via data dashboards for analysis.

Smart gateways powered by Intel technology

are also employed and could provide edge analysis that

leads to real time insights and alerts right on the sales

floor.

Check out this article to gain a comprehensive understanding

of how it works.

And who knows-- maybe it could be useful in your next IoT

solution.

It's been a fantastic 2018, and we want

to thank you all for watching.

We look forward to bringing you more news from around Intel.

And from all of us here in the studio, happy new year.

For more infomation >> Scanalytics Inc. Detailed Analytics of Customer Flow | IDZ Weekly | Intel Software - Duration: 1:55.

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Software Gets You FREE, Unlimited Buyer Traffic TO ANY OFFER : How To Make Money Online - Duration: 4:43.

did you know it's possible to click a few buttons and get unlimited free

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For more infomation >> Software Gets You FREE, Unlimited Buyer Traffic TO ANY OFFER : How To Make Money Online - Duration: 4:43.

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Software-Accessibility: Was soll schon schiefgehen? - Duration: 5:12.

For more infomation >> Software-Accessibility: Was soll schon schiefgehen? - Duration: 5:12.

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Simtoon Software - Vlog 1 - Duration: 1:34.

For more infomation >> Simtoon Software - Vlog 1 - Duration: 1:34.

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Budget-Friendly Photo Editing Software for Photographers | ASL - Duration: 7:22.

Whether you use a camera or your smartphone camera, you should edit your pictures

Editing makes them seem more professional, and more unique

So that your pictures stand out from everyone else's.

Hi! I'm Jen C.

Before I start the list, I want to say this is not sponsored. No one is paying me.

I'm just ...giving you some options.

Everyone knows about Adobe Photoshop and Lightroom (abbreviated as PS and LR)

I found a few alternatives that are affordable. Some are even free.

If you're a casual photographer, or just take occasional pictures of your kids

or on special events, vacations, etc.

you might not want a monthly subscription plan for something you use a few times a year.

That's why.

We'll start with smartphones.

I like Snapseed.

It's good. Flexible. It has presets similar to Instagram's.

If your phone can photograph in RAW, this app can edit that.

The other option is VSCO

It's popular. But the really good presets cost extra.

If your phone can shoot in RAW, or with a DSLR, you might want a more powerful software.

I like...I'm going to fingerspell a lot.

Fingerspelling a lot.

I like RawTherapee and Darktable.

(spells)

Both are good RAW editor

They can edit in JPEG if you prefer.

They're very similar to Lightroom.

Both are free.

The next option is GIMP.

It's supposed to be a Photoshop substitute,

but it can be a struggle to use, and I used Photoshop before.

I think it's similar to Photoshop 3, from about 10 years ago.

It's not user friendly. The learning curve is steep.

Very challenging.

Because it's so challenging -- and I'm experienced -- I only use it for fixing dust spots.

That's it. And for everything else I use either Darktable or Rawtherapee for the other edits.

The next options aren't free, but it's a one-time fee.

No subscriptions.

The next...we're on number 3...Capture One

(spells)

It's very similar to Lightroom. It might be a good option if you want a professional software without a subscription.

It's about $300 for the pro version.

Next...four. Luminar.

About $70

I'd call this a hybrid of Photoshop and Lightroom.

It has some features from Lightroom, and some from Photoshop. But not everything.

It's not bad.

It has layers and masks. You can clone dust out.

But, unlike Lightroom, it doesn't have a file organization system.

That's one big plus to Lightroom.

Next: DxO Lab. I haven't tried this one out.

It's similar to Lightroom, but it also doesn't have a file organization system.

That's important for some photographers, if you have a tons of pictures.

Then you'd want to have a way to organize them.

Other than that, they're very similar.

You might like it.

The next option, ah, out of all the paid options, I think it's a really good one.

It's called ON1 Photo RAW.

It's very similar to both Lightroom and Photoshop, and it has almost everything that they offer.

It's great.

And it has an organization system. It costs $100 for both plus the file organization.

It's great.

One more. This one is a bonus because...

It's not an official part of this list.

It's called Photopea. Odd name!

It's similar to Photoshop, except it runs in your web browser like Firefox.

It doesn't run on smartphone browsers.

It has almost everything Photoshop offers.

It's free. You might have ads now.

It's a good option.

Before I forget, please hit like...somewhere down there...hit the bell, and subscribe.

I'm going to try keep adding videos. If you have questions, or need help with your photography, let me know.

I'll try and help.

Auto news on Youtube Dec 31 2018

Auto news on Youtube Dec 31 2018

Roger: -and you don't like it because you want your songs on the album!

John: It's not that, Roger.

Roger: Then what is it!?

Brian: "I'm In Love With My Car?"

Brian and John share a moment of agreement while Roger is annoyed

Brian: Maybe it's not strong enough?

Roger: What does that even mean!? "Not strong enough!?"

Freddie: I know I'm late. What did I miss?

John: Discussing Roger's car song.

Freddie has a "makes sense" moment as Roger cooks his "food" with frustration

Brian: Is it strong enough? That's all I'm asking. If I'm on my own here, then...I apologize.

Roger: How does your new song go then!?

Brian: *Come on, Roger*

Roger: "You call me sweet like I'm some kind of cheese!"

John: *what the fuck* Freddie: *I don't know, mate*

Brian: ...It's good.

Roger: wOW

Brian: Oh! Well-"With my hands on your grease gun!"

Freddie: *oh my god*

Brian: That's very subtle.

Roger: It'S a MeToPhOr, BrIaN!

Freddie: *nearly sips out tea*

John: It's just a bit weird, Roger. What exactly are you doing to that car?

Freddie: Children, please! We can all murder each other, but who would be left to record this album?

John: Statistically speaking, most bands don't fail. They break up.

Roger: *DEACON*

Freddie: Why the hell would you say something like that?

Roger: *HOLY SHIT DEACON*

Freddie: Roger, that's only room in this band for one hysterical queen.

Brian: I know why you're angry, Roger.

Roger: wHY

Brian: Because you know your song isn't strong enough.

Roger: *bitch now you've done it*

Brian: *I'm right*

Roger: Is ThAt StRoNg!?

*rip Brian*

Roger: Is THat!?

Roger: Is ThAt StRoNg EnOuGh, BRIaN!?

Brian & John: NOT THE COFFEE MACHINE!!!

For more infomation >> NOT THE COFFEE MACHINE - Duration: 2:20.

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✅ Nespresso Vertuoline Coffee Maker Review - Duration: 5:07.

For more infomation >> ✅ Nespresso Vertuoline Coffee Maker Review - Duration: 5:07.

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طاولات قهوه فخمه, ترابيزات قهوة شيك, تصميم طاولات قهوه,Coffee Table Decorating Ideas - Duration: 3:07.

For more infomation >> طاولات قهوه فخمه, ترابيزات قهوة شيك, تصميم طاولات قهوه,Coffee Table Decorating Ideas - Duration: 3:07.

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Coffee Shop Vlog | Lofi Hip Hop - Duration: 1:29.

Pause because I made this clip too short lol

For more infomation >> Coffee Shop Vlog | Lofi Hip Hop - Duration: 1:29.

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Meghan Markle has 'banned Prince Harry from drinking alcohol, tea and coffee' - Duration: 4:48.

It's no secret that the Duchess of Sussex is thought to be giving the Royal Family a bit of a shake up.

The 37-year-old has brought a fresh, modern vibe to the bunch and it seems her efforts to encourage change don't just extend to her wardrobe and nail varnish choices.

According to a close friend of the couple, Meghan Markle has succeeded in persuading her husband to give up alcohol, tea and coffee alongside her during her pregnancy.

Harry is no longer drinking alcohol, tea and coffee (Image: PA)

Read More

Important New Year's resolution Meghan Markle made before meeting Prince Harry

The Sunday Express reports that instead of poisoning his body with booze and caffeine, the Duke of Sussex is instead opting to drink still mineral water.

And it appears the swap has paid off as it is claimed his family "noticed the difference in him" during their Christmas holiday at the Queen's Sandringham estate in Norfolk.

The source told the Express they thought it was "quite an achievement" for Harry.

They explained: "Considering he's been a pretty brutal drinker since he was a young teenager, it's quite an achievement.

The lifestyle changes have made him happier and healthier (Image: REUTERS)

Read More

Meghan Markle and Prince Harry's New Year's Eve plans 'revealed' after Christmas at Sandringham

"He was always fidgeting and on the go, always looking for the next thrill. He was a great laugh but it was always very full on."

They added: "Now his new regime doesn't make him the most entertaining party guest in the world, but he's definitely more chilled and relaxed."

Another friend added that they thought he was a lot happier because of the changes Meghan has instilled.

The pair will likely be having a much quieter NYE than last year because of it (Image: WireImage)

Read More

Piers Morgan predicts Meghan Markle's parenting style - and it's bad news for Prince Harry

They said: "All she [Meghan] did was show him there's another way to live and he's become a huge fan. He eats well, doesn't poison his body, exercises, does a bit of yoga and is a lot happier."

With this in mind, it's likely their New Year's Eve plans this year will differ greatly from last year, when the couple jetted off to Monte Carlo and Monaco and "partied like tycoons".

It is thought this year they will instead enjoy a holiday involving plenty of rest and relaxation, before they welcome their first child together in the Spring of 2019.

Read More

Meghan Markle pregnant

Why baby won't be prince or princess

Why they announced news on Tour

Why Meghan might have twins

Designer hints he knew about baby news

Clues that Meghan was expecting

Food pregnant Meghan refused to eat

Meghan's mum speaks about news

Rumours began at Eugenie's wedding

Auto news on Youtube Dec 31 2018

Hi, I'm at Pandan Indah's Toyota Showroom today

Let's have a look at the new Toyota Vios 2019

The Vios that we are viewing today is 1.5G

It's the premium spec among all 3 variations

It is using 1,500cc engine with 107hp, and a 7-speed cvt gearbox

Now let's talk about their safety features

It comes with Blind Spot Monitor, 7 airbags

VSC and Traction Control, ABS and EBD

Hill start assist and Front Digital Video Recorder

This is an Electrochromic Rear View Mirror

It'll automatically dim all the glare of headlights coming from vehicle behind of you

The new Vios comes with two additional driving modes

Depending on your driving preferences, you can choose ECO or SPORT mode

My height is 170cm and when seated at back passenger seats, the headroom is left with not much space

however the legroom is obviously very spacious

The wheel of the spare tyre that comes with this specifications is also in ALLOY

This new Vios comes with pedal shift and sequential gear stick

It'll come in handy when overtaking by easily controlling the seven gear through these.

It also has sensors at front and rear as well as blind spot monitor

The new redesigned center consoles comes with AUTO air-cond

There's even a new colour LCD display at the speedometer

It is easy to park or handle this car with the Panoramic View Monitor

The buttons on the left of the steering is used to control the DVD consoles

while the buttons on the right is used to control the MID (Multi Information Display)

Sadly this car does not comes with Auto Cruise

Vios has always been the best seller of it's class for years due to the durability of the parts.

Thanks to Wing Hin Motor Sdn Bhd for giving me the chance to review this car

Remember to share this video to your friends that likes Vios!

Auto news on Youtube Dec 31 2018

My name is Dino I came here from Croatia

Last year in December I had LASIK for hyperopia and things didn't quite turn out well.

I had a lot of glare starbursts, smearing of the image

like especially at night or in dim lighted areas

like restaurants or cafe bars or something like that.

And then it kind of changed my life, I became anxious

and really stressed about it, but then I had an enhancement

2-3 months ago in September, but it didn't help

I searched online for answers all over the place

and heard about Dr. G and Laserfit.

In Europe there are a couple of Scleral lens fitters but I wanted to go to the best

because I wanted to get the best fit and solve all of my problems

So when I came here, Dr. G saw me, he did the scans,

and like really like the second... the 3rd day we had a lens

that removed all my higher order aberrations and fit quite well.

And now it's my last day and this lens that one I am wearing right now

is really really comfortable and I can see.. there are no more starbursts..

no more glare, no more like the contrast is like seeing in HD.

Aniska: and what was your expectation before coming here?

I didn't know what to expect you know I came here from Croatia to America

for the first time alone, I thought 'please give me hope'

you know, when I saw my topography it wasn't like really good,

but it was a miracle you know.. so all the aberrations are gone.

(Aniska): And how has your experience been with the Dr and the staff?

Yeah the Dr and the staff Ashley and Aniska were really good teaching me how

to put in and take care of the scleral lenses.

Dr. G was really nice and polite and really heard all my problems

and worked really hard to get the right lens and also he talked to me

about everything, about each aspect of my problem and he

did a little bit of his artistry and he did it.

(Aniska): and how has this lens changed your life?

Well I just put it in and uh.. I think I can get my social life

if you know what I mean back because now I can go out without

using pupil reduction drops in my eye, so I can go out and be a normal young guy

(Aniska): and would you recommend us to others and if so why?

Yeah I would definitely recommend to anyone who has Keratoconus, LASIK,

LASIK ectasia all any kind of corneal issues to come here

scleral lenses will change your life because it did mine

For more infomation >> Dino, man with LASIK damaged eyes gets vision restored in Texas - Duration: 3:25.

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What's Up South Texas!: Boy on autism spectrum dominates the game of Scrabble - Duration: 3:09.

For more infomation >> What's Up South Texas!: Boy on autism spectrum dominates the game of Scrabble - Duration: 3:09.

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Texas Rangers investigating officer-involved shooting - Duration: 0:20.

For more infomation >> Texas Rangers investigating officer-involved shooting - Duration: 0:20.

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Texas Live! gearing up for NYE event - Duration: 1:22.

For more infomation >> Texas Live! gearing up for NYE event - Duration: 1:22.

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Architecture in State Parks, UT Gulf Coast DesignLab - Texas Parks & Wildlife [Official] - Duration: 13:58.

- What's up?

- NARRATOR: It is early summer, and these University of Texas

students are preparing for a trip.

- Is it open? - I think so.

- ANDRE: We've got 12 students, and our professor.

- NARRATOR: The group is heading from Austin

to the coast...

- We're heading down to Galveston Island State Park.

- NARRATOR: ...But not for a break on the beach.

- ANDRE: Today we're packing up for the first site visit.

- NARRATOR: These advanced architecture students

are heading to Galveston to design and build.

- Toodle-oo!

- Bye!

- NARRATOR: All anyone can say for sure is that,

by the end of this summer, a lot will be learned.

- COLEMAN: This is a project we have to do

in a very short time.

Ten weeks from the first day to the last day.

It will be an interesting summer for these students.

- NARRATOR: If they are successful, the end result

will be a finished structure that the state park needs.

[upbeat music]

[waves crashing]

- Welcome to Galveston Island State Park.

Super excited that you're here.

I'm a Park Interpreter.

Essentially, I try to connect people with the

natural resources that we have.

We are almost an island within an island,

surrounded on all sides by development.

- NARRATOR: Since Hurricane Ike in 2008,

this park has operated with limited infrastructure,

until a re-development plan can be funded.

- As we get out here, you might notice some algae on the ground,

you see the little bubbles?

- NARRATOR: One pressing need is a pavilion for

educational programs...

- So, it's a nursery habitat for all the fish that we like.

- NARRATOR: ...a structure to provide some of the only shade

on the park's bay side.

- We have a lot of school groups that come out here.

I have a lot of hurdles to get over in order to make them

start to care about this place.

To get them to some of those higher thoughts

and higher concepts, you have to meet their basic needs.

- COLEMAN: The students are concentrating on working

closely with their stakeholder, the park rangers.

- This is the proposed site, with an emphasis of

orientation towards the water here.

- COLEMAN: They're going to try to get an idea of what

it is that they want, and through that they'll begin

a design process.

- PATRICK SCHOONOVER: Hit that corner, Joey?

- COLEMAN: They'll be camping very close to where

they're going to build.

It gets them immersed in the climate they're going to be

working within.

[waves rolling]

The mission of the DesignLab

is to try to increase ecological literacy,

particularly of the coastal environment.

[dramatic music]

- REBECCA KENNEDY: How many renders are there going to be?

Four?

- ANDRE: Yeah. - Okay.

- HUGO: That's much better.

It's been like Santa's little workshop in here.

[playful music]

- COLEMAN: What are you working on?

- A lot of cardboard, a lot of Elmer's glue.

We spend a lot of time at Hobby Lobby.

Sweet.

We're getting a Master's in Architecture

but we're getting a Ph.D. in craft supplies.

- We had a pretty long design process.

Obviously, designing something with a group of 11 people,

it's hard to come to a consensus about things.

- We floundered for about a week there to try to really

find something we could all get behind, um,

but that's great, because that's how real-world practice is

and it also ensures that we have a really good, strong idea.

Given that it's a shade pavilion, we can test if it

really does provide shade.

I can hit 'apply' and then we can see that at 10 AM,

we're getting dappled light through the structure.

[playful music]

- COLEMAN: These early models are design studies that they

were doing individually.

They're all meaningful in that they lead to something.

That one design that they're actually now going to present.

- It was a little bit Frankenstein-y

for a little while, but we've got something good here.

I think it's, uh, definitely come together

as a collective idea.

- You know, everything that we're doing now,

we're trying to minimize long-term maintenance.

Things really get beaten up.

- COLEMAN: We have milestones that we have to hit.

And the big milestone of the first half of the semester

was getting the design and presenting that to the

folks at the park.

- That's the shoreline we're counting.

- I like your orientation.

I think it's very good.

So, your prevailing breeze is coming from the water.

- The next milestone then is develop drawings

and to get the technical folks with the Parks Division

to approve that.

- When you walk around the corner and it all kind of

opens up in front of you.

I just think that's a great idea.

- COLEMAN: We will have about two and a half to three weeks

to actually put this thing together,

so it's very fast-track.

- HUGO: Fabricating components.

[buzzing]

- We've been getting a lot of welding practice

and sweating a lot.

[laughs]

[saw revs]

- There's a team working solely on wood,

a team working on mostly steel,

so that allows us to work really quickly.

- Theoretically, we're supposed to start this uh, this Friday,

making shade.

- ANDRE: We had a few setbacks.

We had our professor take a little spill earlier,

but he's getting sutured up,

so I think he'll be good in a couple of days.

- REBECCA: I just hope he's alright.

- Cut going this way.

We're figuring out how to load a lot of wood

without a leader right now.

We've probably got three or four tons of wood.

Not a cool day.

I don't know what it is, 100?

103? Ugh.

- You got it?

- REBECCA: Phew.

Ay yay yay.

Well, alright.

We're kind of in limbo of like when we're actually

going to have the clearance to begin building.

- BROOK: One, two, three.

[sighs]

- ANDRE: We just have to go and check all the boxes,

make sure everything is good to go.

[door rolling shut]

[wind]

- HUGO: Found a way to get through all the

procedural hurdles, and we're moving forward.

- COLEMAN: You know, it was right down to the wire.

On the day we started construction is the day

we got our approval.

So, all's well that ends well is what I say.

- HUGO: We lost a day on the front end, but for the

most part we are on track.

[upbeat music]

A lot of dirt has been dug.

- SEAN: Getting there.

- HUGO: It was extremely hot the first couple of days,

I think it was record highs,

but the human body is pretty resilient.

- Woo!

- HUGO: We've been doing great.

Great attitudes all around.

- In that direction, yeah.

What's your suggestion?

- HUGO: Our fearless leader is back on site.

We couldn't be happier to have him.

- I had a few stitches in my face which set me back

a few days, but the truth is, this is such a good group,

they're totally independent.

[dramatic music]

- HUGO: You have to, essentially, in space,

make a perfect square, and determine perfect placements,

which is surprisingly challenging to get it right.

You know, especially if you don't do it every day.

Measure 20 times, build once, is kind of what we're going for.

- REBECCA: I think we all were really excited today

when all the rocks went into the wall.

We were all like, "Wow, it actually does

what we want it to do," which is pretty exciting.

- HUGO: That's why the studio is so fantastic,

because it bridges that gap between paper and real life.

Are we doing okay?

- I think you're doing great.

- Alright!

- SEAN: Not to jinx anything, but it's been going really well.

- What's your time on those, I'm just curious?

One?

Okay.

- We've had some sequencing things where we've

had to kind of stop and pause and make sure

we're not stepping on our own toes as we go,

but I would say it's been surprisingly smooth.

- This is our second to last cut.

[saw revs]

We've been getting a lot done despite the odds,

and, knock on wood, nothing else comes up.

[thunder clap]

- SEAN: The weather has been our biggest hang up I think.

- HUGO: Here comes the rain.

Let's uh, let's get some stuff put away.

[rainfall and thunder]

- COLEMAN: Working in August, it's both a gift and a curse.

We've probably lost a few hours to summer rains,

but you build that into the schedule,

knowing that's going to happen this time of year.

[thunder]

We have had nothing but a great relationship with

Texas Parks and Wildlife, and this is our fifth project.

We've done three projects at Goose Island State Park,

down in the Rockport area.

The fire circle for the youth nature interpreter there.

A birding platform, where the nature interpreter, again,

uses that for her bay walks.

We've done a project at Sea Rim which is up at Port Arthur.

It's a camping platform that's out in the wetlands

that the only way you get to it is kayaking.

People can rent for the weekend.

It's also used by biologists, bird counters, to keep tabs

on the health of that particular wetland.

So all of these projects have something to do with the

ocean environment, bay environment,

where the public comes and learns something

about the local ecology.

[rocks banging]

- ANDRE: Here we are, it's like 95, 100% humidity

and we got the chain gang out here with rocks.

- They're just masochists.

They just wanted to do it.

[energetic music]

- I'd rather be moving rocks than lifting louvers.

- ANDRE: Yeah, those are probably 80 to 100 pounds,

depending on how soaking wet they are.

- HUGO: Oh yeah.

Oh yeah!

[grunts]

It's almost there.

It's been a very laborious undertaking,

but we are on the tail end now.

Just the finishing touches- the fun part really.

[rocks clanging]

[water pouring]

[drinking]

- And repeat.

[energetic music]

- It's tough to work in these conditions for

12 hours a day.

When you can see the finish line, it's a lot easier.

- HUGO: We're going to finish, guys.

I can't even describe the level of happiness

that makes me feel.

- When they put up the first six louvers,

we were like, "Oh my God!

"We're standing on the deck and it's shaded!

We did this!"

- HUGO: One, two, three.

Teamwork makes the dream work.

Alright, let's drill it.

[energetic music]

- JOEY: We had some rough days in the beginning.

- We really were questioning whether we would even

be here right now.

- It was pretty tough.

I'm really happy about the result though.

- Because we're kind of wrapping it up,

we're finally seeing what we've made come to life.

I wish we could see the first group that's

going to experience it.

- HUGO: I'm pretty happy.

I'll come back sometime,

but I'll be happy to drive over the bridge,

headed back to Austin.

- I will not feel guilty if I lay in bed all day tomorrow.

[drill hammers]

- Last one!

Amazing experience.

- Nice work.

[laughs]

[broom scraping]

- SEAN: We're excited to be wrapping up today, for sure.

[uplifting music]

- ANDRE How about this group shot?

- SEAN: I hope they're as satisfied with it as we are.

- Y'all ready?

- SEAN: For us, it's a win at least.

- One, two, three.

[shutter]

[laughs]

- Digging the shade.

Above and beyond.

I love this crew.

This is amazing!

So, lessons learned?

- COLEMAN: Do this in November.

[laughs]

- This place I think is going to be highly used,

and, of course, I think the shade is going to be

really appreciated in the future.

Please consider this a personal invitation

to come back and see how this place lives.

- There isn't like a ribbon cutting ceremony or anything.

- LISA: High five.

Yes.

Good game, good game.

- SEAN: There will be some mild celebration

and then some careful driving home,

because I think we'll all be very tired.

- LISA: Good game, yeah, America.

[uplifting music]

[wind and uplifting music]

[uplifting music]

Auto news on Youtube Dec 31 2018

Bullous pemphigoid is an autoimmune skin disease that causes the skin to form bullae or blisters.

Now, the skin is divided into three layers--the epidermis, dermis, and hypodermis.

The epidermis forms the thin outermost layer of skin.

Underneath, is the thicker dermis layer, and finally, there's the hypodermis that anchors

the skin to the underlying muscle.

The epidermis itself is made of multiple layers of developing keratinocytes - which are flat

pancake-shaped cells that are named for the keratin protein that they're filled with.

Keratinocytes start their life at the lowest layer of the epidermis called the stratum

basale, or basal layer which is made of a single layer of stem cells, called basal cells

that continually divide and produce new keratinocytes.

The stratum basale also contains another group of cells called melanocytes, which secrete

melanin.

Melanin is a pigment protein, or coloring substance.

Below the epidermis is the basement membrane which is a thin layer of delicate tissue containing

collagen, laminins, and other proteins.

Basal cells are attached to the basement membrane by hemidesmosomes, a protein complex that

stems from the bottom of the basal cells.

Just like an anchor digs into the seafloor and holds a boat in place, hemidesmosomes

dig into the basement membrane and hold basal cells in place.

The exact cause of bullous pemphigoid is unclear, but it's thought that in a person with a

genetic precondition, it can be triggered by medications like furosemide, captopril,

penicillamine, non steroid anti-inflammatory drugs (or NSAIDs), and antibiotics.

Bullous pemphigoid is a type II hypersensitivity reaction, which is when the immune system

produces antibodies that bind to the body's own cells.

Immune cells called B cells produce IgG antibodies, which are Y shaped molecules with 2 regions,

an antigen binding fragment region - or Fab region, and fragment crystallizable region

or Fc region.

The Fab region of the antibody binds to pathogens which helps other immune cells destroy those

pathogens.

The antibodies can also activate a part of the immune system called the complement system,

which destroys the pathogen, or induces inflammation.

In bullous pemphigoid, the Fab region of IgG antibodies bind to proteins that make up the

hemidesmosome: one of the proteins is called bullous pemphigoid antigen 1 or BPAG1, which

is also called dystonin, and another protein is called bullous pemphigoid antigen 2 or

BPAG2, which is also called BP 180 or type 17 collagen - lots of names for the same thing.

The Fc region activates the complement system.

The process gets started when C1, the first of the complement proteins, binds the Fc region

of the antibody.

C1 then engages other members of the complement family - C2 through C9, some of which are

activated by being cleaved or chopped by an enzyme.

The cleaved fragments C3a, C4a, and C5a act as chemotactic factors, meaning they attract

certain cells, in this case the mast cells.

The mast cells degranulate and release molecules like tumor necrosis factor alpha, leukotrienes,

and cytokines.

These molecules attract inflammatory cells like neutrophils, eosinophils, macrophages,

and T cells.

These inflammatory cells then secrete proteolytic enzymes, which destroy the proteins of hemidesmosomes

- BPAG1 and BPAG2.

Now, If an anchor breaks it can no longer hold the boat in place and it floats away.

So, when the hemidesmosomes are destroyed the basal cells separate from the basement

membrane, and a split forms between the dermis and epidermis, resulting in what's called

a subepidermal bullae.

These subepidermal bullae are distinct from the epidermal bullae which form in the disease

pemphigus vulgaris.

In fact, in pemphigus vulgaris the bullae form as a results from breaking connections

between cells within the epidermis.

Now in bullous pemphigoid, the inflammation also affects the melanocytes, which produce

more melanin that gets stuck within the cells of the dermis.

Bullous pemphigoid is most commonly located on the lower abdomen, flexor side of the forearms,

and anterior or inner thighs, but can also involve other areas as well.

Unlike pemphigus vulgaris, it doesn't typically involve the oral mucosa.

Early on, there's a red and itchy rash, and over time it develops into large bullae

or blisters.

The blisters typically evolve over a few days, and leave behind crusted lesions that heal

without scarring.

A classic way to help distinguish bullous pemphigoid from other skin diseases like pemphigus

vulgaris is the Nikolsky's sign - which is when lateral pressure is applied to the

lesion, and it causes a split to form between the upper and lower layers of the epidermis.

In bullous pemphigoid the skin doesn't split.

Pemphigus vulgaris will have the Nikolsky's sign, but bullous pemphigoid will not.

In addition, a skin biopsy can be done to look for evidence of antibodies and complement

infiltration into the skin.

Finally, the blood can be checked for auto-antibodies against BPAG1 and BPAG2.

Bullous pemphigoid is most commonly treated by stopping any medications that could be

triggering it and by using corticosteroids.

All right, as a quick recap, bullous pemphigoid is an autoimmune skin disease mediated by

type II hypersensitivity.

Autoantibodies form against BPAG1 and BPAG2, and they allow blisters to form between the

dermis and epidermis layers.

Large tense blisters on the lower abdomen, arms, and legs are the most common symptom.

There is no Nikolsky's sign, but there are circulating IgG antibodies, and it's usually

treated with corticosteroids.

Auto news on Youtube Dec 31 2018

Despite it being well past Christmas, I had a list of holiday cocktails I wanted to do,

and god damn it I'm still gonna do them all.

Today, we're making the casserole of cocktails--mulled wine, where you just dump in all the fruits

you didn't use during cooking.

A bit of an exaggeration, I know, but mulled wine is something delicious you can easily

make with spices you already have in the house.

I'm gonna grab myself an orange, a lemon, and a lime.

Start by peeling the lime, I just want the skin and not the juice cause otherwise this

is gonna be too sour (for me).

Struggle with it cause you suck, and that's when you switch to your trusty old zester.

Not sponsored by Microplane obviously but holy shit if you're getting a zester, get

a Microplane cause if you zest often, at the end of the day, you're gonna have to end

up buying one of these anyway.

Also gonna zest a lemon.

I know it's not the most beautiful lemon out there but it's so darn hard to find

good lemons in Taiwan.

All they got are limes for some reason.

Orange peel.

For this I'm gonna switch back to a knife cause the skin was too tender.

We'll also cut the orange into slices and squeeze out all its juice.

Spices!

In the same pot, that was one whole cinnamon stick.

4 cloves cause cloves are wonderful.

1 and a half star anise, you can definitely put more, but for some reason I always taste

the star anise more than I can taste other spices.

One bay leaf because let's face it, you're always gonna forget to use it when you're

cooking anyway.

And a few gratings of nutmeg.

80 grams of sugar which is a little more than a third of a cup if you're not using a scale.

Uncork your wine.

Now the inside of your pot probably looks something like this.

Pour in enough wine to at least cover the sugar.

Cook on low to medium heat until the sugar completely dissolves.

There's usually 2 methods I've seen with this, 1 is to cook this into a syrup.

The second method is to cook everything without bringing it to a boil, then let it sit in

the fridge overnight so it has time to infuse.

What we're trying to achieve is the same though, which is bring out as much flavor

as we can from the spices and citrus without compromising the wine too much.

I want to drink it right away, so I'm gonna let this cook for a while then pour in the

rest of the wine and let that heat through.

Taste to see if there's anything you need to adjust.

I'm gonna add a splash of brandy.

Now it's ready to serve.

Garnish with a cinnamon stick, and that's pretty much it.

Enjoy your homemade mulled wine.

Everyone and their mother has their own version of this drink, so whatever gets you happy

and drunk is good mulled wine in my book.

And since I only used one bottle of wine, that means this recipe serves...I don't

know, one?

Anyway, have a great 2019 guys.

I'm gonna go get drunk now, bye.

For more infomation >> An Amateur's Guide to Mulled Wine | 香料熱紅酒 - Duration: 2:51.

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The Ultimate Guide To Activated Charcoal - Duration: 6:18.

For more infomation >> The Ultimate Guide To Activated Charcoal - Duration: 6:18.

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Girls' Frontline - 5-2N RF Dragging Guide - Duration: 3:31.

Hello everyone, Ceia here.

Today I'll be introducing a method we've been testing out - which is 5-2N Rifle Dragging.

The rifles needed for this particular method would be - WA2000, SVD or M14.

You will also need these 4 specific handguns for this route.

If you do not have five-seven, you can replace her with PPK.

You will need 3 echelons for this route

A fodder echelon, a rifle to resupply and your main echelon.

You go along this route.

The 20,000 node that you'll see later occupying the middle captured helipad does drop green rarity equipment at a fairly decent rate.

This method nets you better equipment enhancement fodders than 3-2N RF dragging or 5-2N MG Dragging

In exchange for not having any corpses to be leveled. Only use this method to farm equipment fodder only.

The objective of this Rifle Dragging is to not allow the cannons to fire off a single shot at your handguns. Else your handguns will take too much damage for this to be cost effective

This route contains only armored units, so if you want to do your weekly armor kill quests, you can use this method as well.

This route will be much easier to manage once fairies are released. If you don't want to get cancer from 6-3N Zas Dragging or 3-2N RF Dragging, you can use this route instead.

Swap your handgun fodder echelon and main echelon around and retreat.

I hope this video has been useful to you, if so, perhaps give me a like, perhaps subscribe, share this video with your community if it has helped you.

and i will see you guys, next time

For more infomation >> Girls' Frontline - 5-2N RF Dragging Guide - Duration: 3:31.

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How To Start A Bullet Journal: Your Complete Guide - Duration: 5:15.

(jazzy music)

- Bullet journaling is a do-it-yourself, create-it-yourself

diary, calendar, journal, dream list, place to doodle.

An opportunity to make a tool that

works specifically for your life,

which is also an opportunity to learn about your life.

- How do you start a bullet journal?

I would say get yourself a notebook,

and it doesn't have to be anything special,

just a simple notebook, and a pen.

- Step two, write down what you want to track.

Look at it in these pieces of what are you doing in a year,

what are your goals for the month,

what are your goals for the week.

All of those things can be tracked together,

and can really help you look forward for the next month,

to figure out how to better prioritize your life.

- For folks that are scared because it's like,

it may organize your life too much,

or you like flexibility, this actually affords you that.

- A helpful thing for me is just to use the basic principles

of bullet journaling, which is an index, a future log,

a monthly calendar, and then rapid logging.

- The index goes first, you write what page something's on.

- The index basically will be kinda your table of contents.

- And then you can find it, instead

of having to flip through it forever.

Some people do really cute doodles.

I love that, I tried once, and then I got lazy.

- Here's the key, really handy.

Consistent indicators for you to kind of

process your bullet journal as you go along.

- This is a bullet.

- The dot is something you need to get done.

- Update resume, haha.

- Next to it, I might write laundry.

- Chapter four, talk to this teacher.

- Call my mother.

- Get these books from the library,

return these books from the library.

- Buy a new notebook on Amazon.

- You X it out when it's done.

- If you're doing a really good job,

you'll see all your little lines of X's in front of them,

so you're really kicking butt.

- You migrate with it a little, I don't know how to say it.

- Migrated is the symbol for failure,

which means, no, just kidding.

- This is what I would use to transfer the fact that I

didn't buy that notebook today to the next day.

- You didn't get to it that day, and you are moving it

to another week or time, or the future.

- This is an open circle.

- Oh, and that's really handy.

I use it mostly for the future log, like oh, we're having

a meeting with very important people on the 13th.

- This is a dash, which is what I use to designate a note.

- That gets really handy when you're in a meeting

or something, where it's like oh, this is information,

and then ha, here's something that then I have to do.

- At the end of the week, as you start to think about

writing your next week of events, you can take stock

of what you've completed and what you haven't.

- When something's like, you know what, I don't really

need to do this, so you mark it off as irrelevant,

you just cross it off, and it feels so good, goodbye.

- I normally do about five times I'm allowed

to keep pushing something off, but then if I keep

pushing it off, then I know I'm either never gonna do it,

so I gotta do it right away, or I have to be like,

it's not gonna get done, I'm just done moving it.

'Cause, you know, there's only so much room on a page,

so I can't really keep things there that

aren't actually, you know, going to get done.

(calming music)

- Took me a while to find a system that worked for me,

and really, it's the monthly layout once a month,

and then these weekly layouts.

- My favorite layout is the six-month

future log, and the weekly layout.

- Keep it simple, like know what you're going to use it for.

There's a lot of really great ideas out there,

but if they don't resonate for you, you're not gonna use it.

- I tend to use color coding more than different layouts,

as my kind of signature style.

This is October, I used orange for October.

- My habit tracker.

I list the medications I have to take,

different healthy habits.

- I have the dates across the top in this one,

and then just the habits that I'm aiming for on the side.

And I try to group them up, so at the top,

I have spirituality, fitness, and general health stuff.

- I track how much water I drink.

- My sleep hygiene, make sure I get eight hours.

I have one for make bed, but I only filled it in once.

So then the next month, that would just be off the list.

(calming music)

- Having it written down takes it out of my mind

and allows me the freedom to live my life

in a way that is not just drowning in details constantly.

- This is so much more tangible, and I'm a lot more

proud of this, in a weird way,

than I would be of a computer calendar.

Sometimes batteries die, so this never dies.

- Makes me feel very productive.

- Checking off a task makes me really wanna do the task.

- Every time I fill in one of my action item boxes,

I do a little dance in my head.

- I mean, I thought I was freakin' efficient,

like I'm hella more efficient now.

(calming music)

- Bullet journaling is awesome.

It's really helped me get in touch with myself,

and I really, I love it, I think that it's

a great system that anyone can use.

For more infomation >> How To Start A Bullet Journal: Your Complete Guide - Duration: 5:15.

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Message du 31 décembre 2018 / Guide en Libération Bienveillante - Duration: 3:56.

For more infomation >> Message du 31 décembre 2018 / Guide en Libération Bienveillante - Duration: 3:56.

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Beginner Guide: So wecheln Sie RICHTIG Etiketten beim Blitz Auszeichner! | Hutner B2B - Duration: 4:55.

For more infomation >> Beginner Guide: So wecheln Sie RICHTIG Etiketten beim Blitz Auszeichner! | Hutner B2B - Duration: 4:55.

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LeBron hits triple-double to guide LA Lakers past New Orleans Pelicans - Duration: 1:49.

LeBron James had 22 points, 14 assists and 12 rebounds, and the Los Angeles Lakers beat the New Orleans Pelicans 112-104 on Friday night

James got his third triple-double with the Lakers and No 76 for his career, helping Los Angeles to their sixth consecutive home win

 Kyle Kuzma had 23 points, and Ivica Zubac set season highs with 16 points and 11 rebounds

  LeBron James takes aim on his way to guiding LA Lakers past New Orleans Pelicans James dribbles the ball past Julius Randle in a 112-104 victory for the Lakers on Friday night Share this article Share Anthony Davis had 30 points and 20 rebounds for the Pelicans, who lost their third straight game

 Julius Randle scored 21 points, and Jrue Holiday had 18 points and 10 assists.Davis and James shared the court for the first time since James recently declared in an interview with ESPN that it would be 'amazing' if the Lakers traded for the Pelicans' biggest star

 James' comments prompted accusations of tampering.New Orleans coach Alvin Gentry said before the game that Davis will not be traded to the Lakers or anywhere else as long as he remains under contract to the Pelicans

James had 22 points, 14 assists and 12 rebounds to guide Lakers to sixth home win in a row James got his third triple-double with the Lakers and No 76 for his career against the Pelicans Share this article Share

For more infomation >> LeBron hits triple-double to guide LA Lakers past New Orleans Pelicans - Duration: 1:49.

-------------------------------------------

LeBron hits triple-double to guide LA Lakers past New Orleans Pelicans - Duration: 1:49.

LeBron James had 22 points, 14 assists and 12 rebounds, and the Los Angeles Lakers beat the New Orleans Pelicans 112-104 on Friday night

James got his third triple-double with the Lakers and No 76 for his career, helping Los Angeles to their sixth consecutive home win

 Kyle Kuzma had 23 points, and Ivica Zubac set season highs with 16 points and 11 rebounds

  LeBron James takes aim on his way to guiding LA Lakers past New Orleans Pelicans James dribbles the ball past Julius Randle in a 112-104 victory for the Lakers on Friday night Share this article Share Anthony Davis had 30 points and 20 rebounds for the Pelicans, who lost their third straight game

 Julius Randle scored 21 points, and Jrue Holiday had 18 points and 10 assists.Davis and James shared the court for the first time since James recently declared in an interview with ESPN that it would be 'amazing' if the Lakers traded for the Pelicans' biggest star

 James' comments prompted accusations of tampering.New Orleans coach Alvin Gentry said before the game that Davis will not be traded to the Lakers or anywhere else as long as he remains under contract to the Pelicans

James had 22 points, 14 assists and 12 rebounds to guide Lakers to sixth home win in a row James got his third triple-double with the Lakers and No 76 for his career against the Pelicans Share this article Share

Auto news on Youtube Dec 31 2018

Auto news on Youtube Dec 31 2018

Auto news on Youtube Dec 31 2018

Excitement builds for Boston's New Year's Eve celebrations - Duration: 1:49.

For more infomation >> Excitement builds for Boston's New Year's Eve celebrations - Duration: 1:49.

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Thousands Expected At First Night Boston 2019 Despite New Year's Eve Rain - Duration: 1:29.

For more infomation >> Thousands Expected At First Night Boston 2019 Despite New Year's Eve Rain - Duration: 1:29.

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Boston ready to ring in 2019 - Duration: 2:19.

For more infomation >> Boston ready to ring in 2019 - Duration: 2:19.

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Security tight for Boston's First Night - Duration: 0:50.

For more infomation >> Security tight for Boston's First Night - Duration: 0:50.

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Boston University College of Arts and Sciences | Wikipedia audio article - Duration: 1:58.

For more infomation >> Boston University College of Arts and Sciences | Wikipedia audio article - Duration: 1:58.

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Thousands Expected At First Night Boston 2019 Despite New Year's Eve Rain - Duration: 1:28.

For more infomation >> Thousands Expected At First Night Boston 2019 Despite New Year's Eve Rain - Duration: 1:28.

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Gift card to closing Boston restaurant? Here's what to do - Duration: 1:54.

For more infomation >> Gift card to closing Boston restaurant? Here's what to do - Duration: 1:54.

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Auto news on Youtube Dec 31 2018

In divorce: Treating pets more like people? - Duration: 1:01.

For more infomation >> In divorce: Treating pets more like people? - Duration: 1:01.

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Judges to consider what happens to pets after couples divorce in California - Duration: 1:37.

For more infomation >> Judges to consider what happens to pets after couples divorce in California - Duration: 1:37.

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Auto news on Youtube Dec 31 2018

Hey what is going on guys welcome back to another video.

Today I am going to be showing you how to get free stuff

on Amazon.