Thứ Bảy, 27 tháng 10, 2018

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-We just want to be good neighbors,

establish trust.

-We want that, too.

-Are you worried about Kai's intentions?

-He's up to something, and that's not good.

♪♪

Someone's in trouble.

That was surreal. Your hotel is haunted.

Show yourself.

♪♪

-[ Screams ]

-I feel your every emotion as if it were my own.

I can't turn this off, and I can't ignore it.

-Then I don't know what to do.

-Bobo has been having these deadly near-misses.

[ Gasps ]

I don't want to lose you

right after we finally found each other.

-The evil in Midnight doomed Creek and me,

and I'm not gonna let that happen to you and Bobo.

I can make out a figure. -Who is it?

My family was cursed by dark witches.

As long as Bobo loves me, he's gonna die.

-Said I would found demons when I fell in love.

He wouldn't approve of this haunt.

-It's a good thing I know how to keep a secret.

-How long have you been working for my father?

-I can explain.

-You are amazing... Manfred Bernardo.

-She discovered Kai's secret.

-What kind of secret would be worth killing over?

♪♪

-I'm not the man you think I am.

-Whatever's happening is supernatural.

-Fiji!

-Oh, God. -That was a vampire.

-Kai.

♪♪

-I can help you now. -Shut up!

-No! No. No. No. I can cure her.

I can take the vampire out.

-That's impossible.

-[ Gasps ]

♪♪

-You can make supernaturals human again?

"Midnight, Texas." Fridays on NBC.

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Midnight, Texas star previews the show's new season - KING 5 Evening - Duration: 1:51.

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'Booneism,' Texas ranch and proud moments: T. Boone Pickens sits down for exclusive interview - Duration: 3:32.

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Lack Of Engineering Study May Make Hundreds Of North Texas Red-Light Cameras Illegal - Duration: 1:08.

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Lack Of Engineering Study May Make Hundreds Of North Texas Red-Light Cameras Illegal - Duration: 5:23.

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Texas Trump Fan Stands Up To ABC's Lies, Buys Billboard To Set Record Straight - Duration: 12:25.

latest news now this is classic a president Trump supporter from none

other than the great state of Texas is using billboard space to slam the fake

news network that is ABC over its coverage of Russian interference in the

2016 presidential election Kyle Courtney of Boerne Texas placed an

ad saying he had grown up with ABC News but has been down by what the network

has turned into by reporting such fake news as the so-called Russian collusion

narrative the Democrats conjured up in order to remove a sitting president

according to Patriot Journal the Billboard reads ABC News I grew up with

you we are through the Russians didn't elect Donald Trump I did perfect

Bernie man announces ABC News shows support for

Trump with large billboard pic Twitter com / qø TCA v and w and the best part

of this whole thing is if you actually take the time to try to access the

Twitter picture you find this it appears the Billboard has upset the

Twitter overseers in a statement to San Antonio Texas NBC affiliate Courtney

said ABC News was the only channel I watched as a child growing up in Texas

but I think they have lost touch with America and forgotten the workingman

courtney then had an awesome takedown of the media by accusing them of acting in

coordination with the hillary clinton campaign during the 2016 presidential

election Hillary Clinton's presidential campaign was funded by the Clinton

Foundation in close coordination with the media and now we're seeing them try

to fix what they couldn't fix during the election Courtney said they are doing

everything they can night after night to create narratives

and sway people's direction to impeach Donald Trump the Billboard has been

confirmed to remain up for two months this is exactly what the media doesn't

understand yet we the people have figured out their game and we won't be

playing it anymore ever since the far-left liberal Walter

Cronkite who had the ear of most of American during the 60s negligently said

on his third-rate news / propaganda show that the Vietnam War was lost the

mainstream media took it upon themselves to form public opinion rather than just

report the news and although it took the American people 50 years and an outsider

as their president to understand they aren't having it anymore make America

great again and don't let the Democrat lapdog media dictate the agenda anymore

here is more on Cronkite via accuracy in media it is wrong to speak ill of the

dead on the other hand it is an insult to the intelligence of the American

people to pretend that Walter Cronkite was the voice of God and universally

credible as Mara liason put it on Fox News Sunday the terrible truth is that

Walter Cronkite symbolized liberal media bias and used that bias with disastrous

secuence --is for our nation and the world his latest cause was world

government and the destruction of American sovereignty we found out after

his retirement that he was not only a liberal which was evident from his

broadcasts but a one world here in appearances before the world Federalist

Association which favors world government financed by global taxes he

called for the u-s to renounce some of its sovereignty and pass a series of

united nations treaties many of which are now being pushed in the Senate by

President Barack Obama Cronkite called for an international

Liberty Bell he called for Senate ratification of the treaty to Ban

Landmines the law of the sea treaty the

comprehensive nuclear-test-ban treaty the convention to eliminate all forms of

discrimination against women and the Convention on the Rights of the Child

most important he said we should sign and ratify the treaty for a permanent

International Criminal Court which would violate u-s constitutional rights by

enabling foreign judges to prosecute American citizens and imprison them in

foreign jails Cronkite was determined to use the U n and its treaties to inhibit

the ability of the u.s to act in its own national security interests one of

Cronkite's appearances where he accepted a global governance award is available

on video at an event which featured the wife of venue and boss Kofi

and a video from then First Lady Hillary Clinton the same global governance award

had also been given to former Time magazine columnist strobe Talbott

another advocate of world government later a top State Department official in

the Clinton administration and subsequently named as a special contact

of the Russian intelligence service by a Russian spy

Talbot now runs the liberal Brookings Institution in 1988 seven years after

his retirement as anchorman of the CBS Evening News

Cronkite addressed a left-wing people for the American Way conference and

announced President Reagan for the unilateral military actions in Grenada

when the u.s military evicted a communist gang and Libya when Reagan

ordered a military strike in retaliation for the acts of terrorism against

Americans Cronkite despised Reagan's peace through strength policies and said

that the smartest president he ever met was Jimmy Carter later Cronkite

announced Operation Iraqi Freedom and attacked the Bush administration for its

arrogance his role in the Vietnam defeat is being reported as if it were a

highlight of his career yet his misreporting helped create the

conditions for a premature u-s military withdrawal leading to the loss of the

lives of 58,000 Americans in vain not to mention the millions of additional

deaths caused in Vietnam and Cambodia by the Communists Cronkite's public verdict

that the 1968 Tet Offensive was a defeat for the u.s is widely seen as a turning

point in American support for the war cronkite falsely claimed that the

Vietcong had held the American Embassy for six hours and that the offensive

went on for two months the facts show that tent was actually a major defeat

for the Communist enemy accuracy and media founder and longtime aim report

editor Reed Irvine noted that Cronkite contributed a great deal to our defeat

in Vietnam beyond Vietnam Cronkite got it wrong on

one of the big issues freedom vs. Soviet Communism

in the 1974 book TV and national defense Dr

Ernest Lefevre examined how CBS News programs for two years had covered

national security issues and concluded that the news organization was an active

advocate of several national defense positions which were frequently critical

of u-s policy and usually from a perspective that implied or called for a

lesser military commitment and lower defense expenditures in 1972 for

instance the CBS Evening News aired nearly 1,400 presentations supporting

the dovish view contrary or hawkish positions were aired only 79 times asked

about the charges Cronkite displayed the bias that guided

his news program saying that there are always groups in Washington expressing

views of alarm over the state of our defenses we don't carry those stories

the story is that there are those who want to cut defense spending the most

trusted man in America didn't deserve our trust in 1979 he gave an interview

to the Soviet magazine literary Gazette and told Vitaly cobby's that the Soviet

threat was most likely a myth according to the magazine Cronkite went on to say

that I will never believe in a Soviet threat shortly after the interview was

published the Soviets invaded Afghanistan he retired as CBS Evening

News anchorman in 1981 Cronkite ol Dame founder and editor Reid Irvine that he

had been misquoted by kobeesh and that he had a tape recording of the interview

to prove it the tape never materialized Irvine ran into cobby at an

international media conference and the Soviet journalist said the interview was

entirely accurate after Ronald Reagan took office as president and proceeded

to build up u.s national defense capability in the wake of the disastrous

Jimmy Carter years CBS News acted to counter the Reagan effort they aired a

five-part program the defense of the United States in which Cronkite appeared

to tell us that the relationship with the Soviet Union was dominated by the

same old fears and doubts because we didn't have a genuine dialogue

the Soviet communists Irvine noted at the time of the broadcast that CBS gave

us the Kremlin view that it is the United States not the Soviet Union that

is striving for an impossible military superiority while creating fantasies

about Soviet aggression however Irvine noted that Reagan was not

deterred by the CBS News assault but that the momentum behind his election

mandate to rebuild America's defense was weakened somewhat by the constant

repetition by the media that he was spending too much on national security

Cronkite's accomplices in this crusade included dan Rather his successor and

Bill Moyers then with CBS and now with public television for many years Irvine

drew attention to the persistent anti defense bias of CBS News and reported

one has to wonder why the anti defense bias is so strong and persistent at CBS

my own feeling is that it is a reflection of the views enunciated by

Walter Cronkite that show a benign view of the Soviet Union in 1989 while

expressing the hope that the Soviet archives would one day be open to

demonstrate how the Kremlin manipulated American journalists such as Walter

durante II of the New York Times who had lied and helped Stalin cover up his

monstrous crimes that resulted in the deaths of seven to ten million

Ukrainians Irvine added that it will be fascinating to see what they say about

Walter Cronkite who spent two years in Moscow after World War two as a UPI

correspondent and who has been remarkably restrained in his criticism

of that country ever since this may sound harsh but the fact is that

Cronkite was consistently wrong about Soviet intentions and his attitude

dominated CBS news coverage of the old Soviet Union after the Soviet collapse

Irvine wrote a 1990 AM report about those personalities who had taken a

benign or even Angela tory view of communism and the Soviet Union in the

years since the 1917 Bolshevik coup d'etat Cronkite was on this list of

doves which also included Hanoi Jane Fonda it is fine to recognize Cronkite

for his long life and many years as anchorman of the CBS Evening News

he captured important moments and reached millions but don't pretend that

he was an objective journalist Cronkite's journalism cost lives and

could have cost many more had it not been for a president named Reagan who

had the courage to bypass the major media and go directly to the American

people with the truth about our crumbling defenses when America was

increasingly vulnerable the country was very lucky to have him in that seat as

anchorman Fox News Sunday host Chris Wallace said in paying tribute no

America was fortunate to have escaped his pernicious influence now we have to

try to escape the fate of world government that Cronkite made his

primary cause later in life which has been adopted by President Barack Obama

and Pope Benedict the 16th

For more infomation >> Texas Trump Fan Stands Up To ABC's Lies, Buys Billboard To Set Record Straight - Duration: 12:25.

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Program helping first-time moms increases influence in Texas - Duration: 1:50.

For more infomation >> Program helping first-time moms increases influence in Texas - Duration: 1:50.

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Hydrogen Deuterium Exchange (HDX) at the Univ. of Texas | Behind the Science - Duration: 5:10.

Welcome to another episode of Behind the Science: On Location.

I'm your host, Jennifer Fournier.

Protein misfolding is believed to be the primary cause

of diseases such as Alzheimer's, Parkinson's, and Huntington's,

just to name a few.

Understanding protein function, as well as misfunction,

is therefore critical in finding cures or treatments

for these diseases.

In this episode of Behind the Science,

let's head to a lab at the University of Texas

to see what they are doing in regards to understanding

the structure and function of proteins.

So I'm here at the University of Texas, at Dallas,

visiting the Chemistry and Biochemistry Department.

And they say that everything's bigger in Texas,

so let's see if that applies to the data.

Hi, Kyle!

Oh, hi, Jen.

I am so glad I found you, because I was just

outside your lab looking at a poster

that you were doing, which is really interesting.

It looked like you're looking at enzymes as targets

for protein therapeutics.

And I heard that you're doing some work

on humanizing the bacterial enzyme,

or bacterializing the human enzyme.

What is that all about?

So it's really interesting.

We actually are interested in understanding

how the human enzyme can work, and as well

as the bacterial enzyme can work in shrinking tumors.

Cool.

But can I make an observation here?

On your poster, I see that these two structures of the enzyme,

in crystallography, look very similar.

But as I'm reading through, it looks like they

have different activities.

How can that be?

So we have this hypothesis that these enzymes that behave

differently while in solution.

So we use a technique called hydrogen deuterium exchange

to understand how they behave dynamically.

All right, well, that sounds complicated.

Could you tell me a little bit more about HDX?

Well, I've seen "Behind the Science" before,

so let's take this to the whiteboard.

Let's go to the whiteboard.

The protein is immersed in a physiologically-relevant buffer

and another identical buffer, replacing

only the water for heavy water, which replaces

hydrogen for deuterium.

Using heavy water allows for the hydrogens

located on the proteins' backbone amide

to catalytically exchange with the deuterium from heavy water

freely at room temperature.

We take advantage of this property

to look at the differences in deuterium in corporation

when the protein is exposed to a ligand.

When the ligand binds, the exchange pattern

changes for a region of the protein.

We can identify these regions using mass spectrometry.

Well, Kyle, I do love a good whiteboard,

but what I love even better is to see science in action.

And my guess is you have one of those instruments

somewhere in this lab, right?

You are absolutely right.

It's right over here, and in fact, I

spend most of my time in there.

So let's take a walk over.

Let's head over.

Here it is.

My home away from home.

All right, let's go on in.

Well, Kyle, they say everything's bigger in Texas,

and they weren't joking.

This is a really big instrument.

You are absolutely right.

For this instrument, we have three components.

This automated robot that allows us to do our exchange.

We take it over here where the robot injects,

where the proteins are cut up, and eluted

over a chromatography gradient.

And it sends it over here to the mass spectrometer, where

we can measure mass to charge.

OK, so you're taking a look at the peptides

in the mass spectrometer.

Exactly.

All right.

Now, one thing I notice that I don't

see on every HDX instrument is this automated platform.

Why do you have this?

So we have this automated platform

to control time and temperature, which

allows us to make reproducible data,

and also to make our experiments more efficient,

where we can run longer times.

OK, that makes sense.

Well, this is a big instrument, so my guess

is you have some big data that goes with it.

You're absolutely right.

Let's take this to the whiteboard

so we can take a look at some data.

Sounds good.

These are sample uptake plots for deuterium incorporation

over time.

We get hundreds of these for a single protein in an HDX

experiment.

What you see is human and bacterial alone in blue,

with ligand in green.

You can see some of the regions have large differences,

while others, we see no change at all.

What we learned from this was that the bacterial enzyme

moves less during catalysis than the human enzyme.

And we learned which regions specifically are moving.

Well, HDX is a really powerful tool

for understanding the dynamics of proteins.

You're right, Jen.

Now that you know how it works, let's get you to work.

Let's go.

Understanding the malfunction of proteins

is critical to developing drugs that

work to target these misbehavers and work to whip them back

into shape.

HDX is a unique and powerful tool

for analyzing proteins and how they interact with drugs.

For more information on the HDX work that you saw today,

check out the link below, and join us next time

for another episode of Behind the Science: On Location.

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