Hello
It's still so impressive to see so many people.
the week has been long and complicated for me.
Monday we presented our research to the National Agency for Drug Safety.
Tuesday it was the council of the order of doctors.
and today I have the pleasure of being in front of you.
This morning I had the immense pleasure of doing a walk with Francis in the Vosges (French mountains).
which, for more than one reason, was extraordinary for me.
I would just like to try to be clear.
cancer there are about 400,000 new cases a year.
we do not address the almost benign cancer.
like small cancers of the prostate, small breast cancers, that's about 180 000 to 200 000 cancers.
we are only addressing the tumor for which there is no treatment today.
that is to say roughly between 180 000 and 200 000 tumors.
It is in these patients that we are trying to develop a treatment.
it's only for those patients.
We do not want to substitute for effective treatments when they exist.
it is only for diseases for which there is no treatment today that we want to be effective.
I came here last year,
and the theme of the conference was an attempt to simplify cancer
and to be able to say, cancer is a simple disease, it's only the Warburg effect.
So I came, it was what I had introduced you at the time
I will come back to this point for 5 to 10 minutes
then we will go on what interests you more
about what we think is a probably definitive breakthrough in cancer treatment.
So that cancer is the Warburg effect, I'm just reminding you a bit for those who were not there
Warburg, Nobel Prize in Medicine, understood in 1920, it was a long time ago, that cancer is a disease of fermentation of sugar
you have here a PET scan of a patient who has been injected with radioactive sugar
and you see that his cancer in the ganglions of the neck and mediastin fixes the sugar
what Warburg says in 1920 is that all cancers fix sugar
and this uptake of sugar that can not be burned and secretes lactic acid is what explains cancer.
So we are in 1920, I will not tell you this story again.
but what Otto Warburg says is that the mitochondria work poorly, he speaks of granules because the term mitochondria does not exist yet
and he says that the granules do not work well
and that there is secretion of lactic acid.
For him cancer is that and it is only that.
And he will have the Nobel Prize for medicine but not for the Warburg effect.
he will die in the 70's
and the second part of his life will be less productive than the first.
but in the cancerology medicine books we started with the Warburg effect which was gradually forgotten to be replaced by molecular biology.
I will quickly go over all this.
So obviously the question we asked ourselves last time : if we understand that cancer is only the Warburg effect, ie a fermentation of sugar
if we understand that it is only that, then the obvious question is how can we lift the Warburg effect?
how can we make the cell burn and when burning stops dividing
so obviously there are the weapons that we know
if you remove the fermenting tissue by surgery or radiotherapy
if you are treating with chemotherapy
and at the time we demonstrated on 20000 mice that a combination of lipoic acid and hydroxycitrate prevented tumor fermentation and tumor growth.
And the last thing that is fundamental for patients is the ketogenic diet.
I would not talk much.
but you will understand easily that when your tumor ferments to sugar it makes sense to reduce its consumption.
what is impressive for me today is that, in a year, we saw in the press the fact that sugar is a poison and is responsible for many diseases
it appeared a year ago when it has been known for many years and it has been more or less concealed.
and we realize that sugar has replaced cholesterol as a great scourge. Cholesterol that we all know perfectly innocent in cardiovascular diseases
on the other hand, sugar is not.
I will not go into more detail about the ketogenic diet
I leave it may be to Francis the pleasure of talking about it.
but on the other hand I come to an essential subject, it's chemotherapy.
then chemotherapy was developed to kill tumor cells.
and here you see a patient who has colon cancer with hepatic metastases
that's what takes light at PET scan
you treat it with chemotherapy
and you see that the Warburg effect is lifted
it stops fermenting and it does not catch glucose
and there is a real debate today on how chemotherapy works.
is it a way to kill malignant cells and have pre-surgical treatment or is it only a way to regulate tumor fermentation ?
and we know that if you treat testicular cancer in young people with chemotherapy, you know that if you have a residual mass of less than 2 cm after chemotherapy
The mass is still there but it breathes so it is not toxic.
so it is very likely that chemo lifts the Warburg effect
the problem of chemo is that it is toxic and that it is not very effective in the majority of frequent cancers
in glioblastoma we have 15% response, in pancreatic cancer we have 15% response
we must agree on the term of response, that is to say, the tumor mass decreases a time but it starts again.
and especially something that is relatively little studied and that is fundamental is that when you take for example pancreas cancer or gliobastoma, then you have a time a response to chemo,
and then after it's terrible, it grows very quickly and the patient dies.
so the most likely it is that chemo damages mitochondria, it kills some cells but it damages the mitochondria
and when you're in those moments or after a chemo, cancer blazes, the patients die with a speed and a frightening frequency
so that one in the other you had some answers but you did not improve the survival
and that explains part of the failure of modern chemotherapy treatment.
this lesion of mitochondria by chemo induces an intense glycolitic syndrome.
Well, I'm going back a little bit on what we've already said about lipoic acid and hydroxycitrate
since a year ago there are publications that confirm that we had reasons and that the data were correct.
So there are some improved lipoic acids that are coming out on the market, one is called the CPI-613 which is in the USA.
There are others who arrive
there are experimental confirmations at the Guido Kremer Lab and at Harvard. All this goes in the same direction.
and there are even American publications that show that patients treated by our protocol or a common protocol regress with chemo-free treatment.
so that's things that are gradually being put in place and are confirmed.
just for those who love biochemistry. So lipoic acid lifts the valve between the mitochondria and the cytoplasm. That is, it allows the tumor to burn again.
And hydroxycitrate prevents leakage to the CRA and prevents the use of glutamine.
All this to tell you, and I will not lose you in biochemistry, all this is widely known and all this makes perfect sense.
so it slows down the tumor in bladder cancer in melanoma in lung cancer, all these are things we already Knew.
So now we are going to move into the second and real part of the topo.
So we had a year ago, different elements that combined together were walking.
but if the patients took lipoic acid and hydroxycitrate alone without anything else, the tumor grew less quickly but did not regress.
men are not like mice.
in mice it resulted in stabilization, in humans it leads to slower growth.
so we had to combine lipoic acid and hydroxycitrate with other things, so we combined with ketogenic diet, with chemo
and at that price we saw beneficial effects, we saw patients who survived
but something else was needed.
and that's what happened over the last year and that's why I'm here.
There is something new today, it is chlorine dioxide.
So that's something you've probably never heard of.
I had not heard about it and it's clearly not my invention.
2 years ago, a patient called me, pancreatic cancer, inoperable, he asks me opinion : "Make a mild chemo and add lipoic acid hydroxycitrate and cut the sugars with the cetogenic diet" i said.
he lives in the middle of nowhere, far from everything. He refused chemo but did not tell me.
and he will live the hell of all the people who resist. That is to say that it will collide with the oncologist of Brive, the oncologist of Bordeaux.
He will find himself alone. And he will take chlorine dioxide.
it's not my idea at all. Nor that of Francis. This is his idea. He heard chlorine dioxide from a friend who also had pancreatic cancer.
but that I do not know. So he will take chlorine dioxide with lipoic acid hydroxycitrate and ketogenic diet
he is still on these legs. It's 17, 18 months since the beginning of the story.
so for those who know about pancreatic cancer, people on real pancreatic adenocarninoma, so fatal diseases, at 3 months or 6 months
to have someone who has no chemo, no radiation and no surgery, except for derivations, who is standing, it is really amazing.
So we were facing someone who was surviving.
so when someone like that comes, the first question that comes to you is "is this guy crazy?"
that's the question everybody is asking
and so Norbert has the kindness to come and I can assure you he is not crazy.
he is a completely normal person
totally measured
and who did not want debilitating chemotherapy and who decided to care for himself.
and I have the chance to invite him to speak at the conservator of arts and crafts
More than a year ago
and I'm lucky that Francis tollen, who will speak after me, is here
and of course we ask ourselves "what is going on?" and "what are we talking about?"
chlorine dioxide or chlorite, which is the mother solution, are things I've never heard of.
So let's go back to the history of chlorine dioxide
So I remind you, the Warbug effect is 1920
the chlorine dioxyde is discovered by Bertholet
It's in 1775 or something like that
This is before the French Revolution.
It's chlorine, it's a cousin of bleach, it's a cousin of Dakin's liquid for washing wounds.
and we understand even before we have isolated germs, that when we wash our hands with chlorinated water (at the time we do not know very well what is chloric hypochlorous, it's chemistry)
that we can sterilize things.
and during the cholera epidemic of 1832
So long before Warburg and well before the industrialization of Saint Amarin
well we can sterilize and Dr Semmelweis who realized in 1840 that bacteria are harmful to women who give birth
well he will wash his hands in water with chlorine dioxide
chlorine dioxide is available over the counter
and that's all the beauty of this
you can find it at the "vieux campeur" (popular french store) for example
everywhere including in the chlorination of drinking water
in the pool water etc ...
so it's an extremely well known molecule
extremely well characterized
and of which we produce 1,5 million tons worldwide
so it's something very well known.
so obviously we gonna ask ourselves the following question :
is there an adjunct to metabolic treatment ?
is it a treatment that can replace chemotherapy?
and if so, how does it work?
So the real questions of scientist.
and so we spend a few months trying to understand what's going on.
the next slide is unfortunately not easily readable, so let it go, but it's for me a reminder.
so if we put chlorine dioxide on the mitochondria, on the cells
then chlorine dioxide boosts mitochondrial activity at concentrations that are highly compatible with human concentrations, and the mitochondria starts again.
so we had probably found what we were looking for, ie the complementary treatment with lipoic acid and hydroxycitrate that we had before and which was not a chemotherapy.
So how is it made?
then you usually buy it in liquid form but it also exists in solid form.
Chlorine dioxide is a free radical, it's a thing that has a very short half-life
so you have to make it.
we did not do it expressly. it's like that.
so you have to mix two things :
an acid, in this case hydrochloric acid
and sodium chlorite
then sodium chlorite is not sodium chloride, it is not cooking salt.
and that's the sodium chlorite you buy to purify your pool water
and you have to wait 3 minutes for a chemical reaction to occur
and you will get after diluted chlorine dioxide
this chlorine dioxide has a particular color, an amber color.
and it's not so easy to activate, the doses must be the same on both sides
you have to wait 3 minutes precisely
if you go too fast, you will drink sodium chlorite which is very abrasive.
and if you put too much acid, it will not be pleasant to drink
but if you do it correctly
there is a molecule called chlorine dioxide that is produced.
I will then describe the few patient cases that were followed
what Norbert was doing and I'm just reporting
first he continued to take lipoic acid and hydroxycitrate
if you do not take lipoic acid and hydroxycitrate at the same time, it's not effective.
the mitochondria must be restarted by the means at our disposal
that is, the metabolic treatment that we know, the ketogenic diet and also the chlorine dioxyde.
and you will at first increase the frequency to arrive at a dozen catch per day
what that means is not so easy, the patient will have to get up at night
but I remind you that cancer grows at night, like the beard
and for those who like me, made guards at the hospital, they know that it is the night that dies the cancerous, it is the night they suffer
because cancer follows a nycthemeral rhythm
rhythm of the day and night
and cancer grows at night.
so you have to take it at night too
because chlorine dioxide has a very short half-life
it's an unstable molecule
you have to make it
must wait
and you have to take, at first, a drop a day
then go up to two, three drops a day
always spaced
and the toxicity of chlorine dioxide is well known
because that's what we use to Chlorinate the water, the pool
but also the drinking water, exetera ...
so you have a literature that is vast
and we know that the doses that are recommended three times are much lower than the toxic doses
but there is not even a very clear toxic dose.
But on the other hand and that's the fundamental point
this treatment only makes sense if the patients follow their illness.
and there are 60 to 70% of patients
tumor markers that can be measured.
it's called PSA in prostate cancer.
it's called ACE in digestive cancers.
it's called the monoclonal peak in myeloma
so we can follow the evolution and that's how we can quickly see if we have an effect or not.
and it's within 15 days, not in 6 months, that you see something.
and if there was a fundamental point in the effectiveness of chlorine dioxide
is that it is unthinkable that patients measure their markers only every two months !
a diabetic is blood sugar three times a day.
for a patient who has sepsis, it is an antibiogram every day.
it can not be admitted that cancer patients measure their markers every two months.
you have to follow these markers closely
and it's only by following them very closely
and with now the emergence of new therapies, that we can progress.
I will now tell you the case of a patient named Marie-Jo
she testified on our website "guérir du cancer"
metastatic pancreatic cancer
inoperable and therefore incurable
she is approximately stabilized for 2 years by chemotherapy
she goes on ketogenic diet but it does not work
the markers are a testimony of the evolution of the disease
you can observe evolution in many ways :
- the patient's face, this is very important
- the way he opens the door to you, it tells you a lot
but you also have radiological exams, clinical analyzes
and you also have the markers.
and you see that under ketogenic diet alone it does not work
the markers go up
this is the phase, I was talking about, where everything burn after chemotherapy
and we know that the patient will die in a few weeks.
and Marie-Jo calls me and she starts, following what Norbert and Francis said, to take chlorine dioxide.
a dozen times a day
with lipoic acid and hydroxycitrate
and you see these markers go down
there are two more points that I did not have on the diagram but it continues to decrease.
so you see a collapse of the markers and obviously Marie-Jo feels better
and his doctor wonders what's going on while being happy to live those moments that we only live once in his life.
Finally, there it is
I do not speak about Francis I think he will talk about it himself.
what we currently have on the first 9 patients
there is a little bit of everything
treated largely by themselves.
on the first 9 patients, all chemo-resistant patients, so chemo does not work anymore
all but one patient with pancreatic cancer are stable at two months
which is unexpected.
and all that without strong toxicity
except for a little nausea and vomiting when the doses are a bit high
in this case it is necessary to reduce the doses.
so we get the impression that we are dealing with something extraordinarily active
so now are going to ask all the questions that go behind.
firstly, is it true is it wrong?
will it be confirmed or not?
it's the uncertainties of life.
then the council of the order of French doctors advised me not to talk about it until we were sure
my opinion is that all this is concordant
between our previous work and what was published after
but obviously all this is confirmed little by little
that's why we went to the National Agency for Drug Security
excuse me the name of the agency changes with each health scandal.
to propose a trial to verify all this.
and obviously the question arises of the place of chemotherapy in this kind of pathology.
to go back on chlorine dioxide,
the way we understand what's going on
the dioxide is extremely small like molecule
dioxide, 2 oxygen, chlorine, 3 atoms
difficult to make smaller
so it goes everywhere
but it's only activated in certain tissues that are the basic tissues...
and when you are in a basic tissue and only the cancerous cells are basic
then your molecule of chlorine dioxide explodes
And so will harm the cells
and produce free radicals.
So we have an extremely small molecule.
It goes everywhere.
It does not need to be carried by a key lock system.
and it will only react roughly with tumors.
So it's infinitely powerful.
This will produce free radicals.
so it's a debate among us right now to find out if these are the same free radicals as chemotherapy.
I can not answer you. I have an opinion but it is only an opinion.
I am incompetent in the chemistry of this kind of thing so I will not say anything.
But it's specific, non-toxic and it's probably the same mechanism as chemotherapy but infinitely more powerful.
so we have to ask ourselves the following questions :
First. Is all this credible?
For that we need time to find out
Secondly. Will we be able to replace chemotherapy with a molecule that costs nothing, is over-the-counter and is extremely specific?
the cost of treatment for 1 year with chlorine dioxide will cost between 20 and 30 €.
Last point.
There are 2 domains that are currently advancing in cancer :
There is metabolic treatment.
I remind you that on a server like PubMed, a medical application server, there is nearly a million publications on "metabolism and cancer".
so it's not an esoteric domain.
and there is the field of immunotherapy.
and how does immunotherapy work?
it is something that is not very clear.
We know that when we make antibodies, that it stimulates lymphocytes etc ...
the point so I wanted to talk to you
is that these white blood cells will kill the tumor cells
but the intermediary with which they will kill them is the cousin of the chlorine dioxide which is hypochlorite.
So most probably we have something in common with what we are trying to do, which is a therapy that apparently does not seem too violent
and all imutherapies at 100,000 or 400,000 euros per year and who probably use the same metabolic pathways.
So the message is : There is something new that is something extremely simple, possibly in the short or medium term, that will replace or supplement chemotherapy.
and which can allow, if the civil society moves, to treat effectively the cancers in the short or medium term.
thank you
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