New breakthrough treatment for women with hardest-to-treat breast cancer
An experimental 'magic bullet' drug has the potential to change the way women are treated for one of the most deadly forms of breast cancer, an expert has said.
Sacituzumab, is an antibody that zeroes in on cancer cells. Like a homing missile, it delivers a 'warhead' in the form of a potent chemotherapy drug. Since it directly targets tumours while avoiding healthy cells, side effects are kept to a minimum.
In a clinical trial involving 108 women with triple-negative breast cancer that had spread around the body, the infused drug caused 'significant' tumour shrinkage, researchers reported.
The women had all previously failed to respond to two or more previous treatments. All had a poor prognosis. Overall, a third of the patients responded to the drug and typical survival time was 13 months.
Nine long-term responders remained free of any disease progression for more than a year.
Senior investigator Dr Kevin Kalinsky, from Columbia University, New York, said: 'I think this drug has the potential to change practice, because the data looks so compelling, even with the relatively small number of patients in the trial.
There's an unmet need for patients with metastatic (spreading) triple-negative breast cancer, and we see significant tumour shrinkage with this new therapy. Triple negative breast cancers are notoriously hard to treat.
They are impervious to normal types of hormone therapy and drugs that target the cancer-fuelling HER-2 protein.
The new drug is also being tested against other types of breast cancer as well as bladder and prostate cancers, said researchers writing in the New England Journal of Medicine.
During the trial only 3 percent of patients stopped taking the drug due to adverse side effects. The main effects seen were hair loss, diarrhoea and fatigue.
Dr Kalinsky added: 'Having smaller tumours can be incredibly meaningful to a patient's quality of life. When tumours shrink, patients are more likely to experience improvement in symptoms, like pain.'.
An experimental 'magic bullet' drug has the potential to change the way women are treated for one of the most deadly forms of breast cancer, an expert has said.
Sacituzumab, is an antibody that zeroes in on cancer cells. Like a homing missile, it delivers a 'warhead' in the form of a potent chemotherapy drug. Since it directly targets tumours while avoiding healthy cells, side effects are kept to a minimum.
In a clinical trial involving 108 women with triple-negative breast cancer that had spread around the body, the infused drug caused 'significant' tumour shrinkage, researchers reported.
The women had all previously failed to respond to two or more previous treatments. All had a poor prognosis. Overall, a third of the patients responded to the drug and typical survival time was 13 months.
Nine long-term responders remained free of any disease progression for more than a year.
Senior investigator Dr Kevin Kalinsky, from Columbia University, New York, said: 'I think this drug has the potential to change practice, because the data looks so compelling, even with the relatively small number of patients in the trial.
There's an unmet need for patients with metastatic (spreading) triple-negative breast cancer, and we see significant tumour shrinkage with this new therapy. Triple negative breast cancers are notoriously hard to treat.
They are impervious to normal types of hormone therapy and drugs that target the cancer-fuelling HER-2 protein.
The new drug is also being tested against other types of breast cancer as well as bladder and prostate cancers, said researchers writing in the New England Journal of Medicine.
During the trial only 3 percent of patients stopped taking the drug due to adverse side effects. The main effects seen were hair loss, diarrhoea and fatigue.
Dr Kalinsky added: 'Having smaller tumours can be incredibly meaningful to a patient's quality of life. When tumours shrink, patients are more likely to experience improvement in symptoms, like pain.'.
An experimental 'magic bullet' drug has the potential to change the way women are treated for one of the most deadly forms of breast cancer, an expert has said.
Sacituzumab, is an antibody that zeroes in on cancer cells. Like a homing missile, it delivers a 'warhead' in the form of a potent chemotherapy drug. Since it directly targets tumours while avoiding healthy cells, side effects are kept to a minimum.
In a clinical trial involving 108 women with triple-negative breast cancer that had spread around the body, the infused drug caused 'significant' tumour shrinkage, researchers reported.
The women had all previously failed to respond to two or more previous treatments. All had a poor prognosis. Overall, a third of the patients responded to the drug and typical survival time was 13 months.
Nine long-term responders remained free of any disease progression for more than a year.
Senior investigator Dr Kevin Kalinsky, from Columbia University, New York, said: 'I think this drug has the potential to change practice, because the data looks so compelling, even with the relatively small number of patients in the trial.
There's an unmet need for patients with metastatic (spreading) triple-negative breast cancer, and we see significant tumour shrinkage with this new therapy. Triple negative breast cancers are notoriously hard to treat.
They are impervious to normal types of hormone therapy and drugs that target the cancer-fuelling HER-2 protein.
The new drug is also being tested against other types of breast cancer as well as bladder and prostate cancers, said researchers writing in the New England Journal of Medicine.
During the trial only 3 percent of patients stopped taking the drug due to adverse side effects. The main effects seen were hair loss, diarrhoea and fatigue.
Dr Kalinsky added: 'Having smaller tumours can be incredibly meaningful to a patient's quality of life. When tumours shrink, patients are more likely to experience improvement in symptoms, like pain.'.
For more infomation >> New breakthrough treatment for women with hardest-to-treat breast cancer - Duration: 9:08.-------------------------------------------
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Family-Based Treatment Group Home | New Heaven Dominion - Duration: 0:52.
The need for intensive treatment services for emotionally troubled children and adolescents
in the Department of Children & Families District Four is reflected in the large number of such
youths currently residing in or on waiting lists for a family home setting.
New Heaven Dominion strives to meet the needs of such youths by developing and maintaining
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Pet Urine Removal Treatment by E&L Chem-Dry - Duration: 3:13.
We love our pets.
They're our BFFs, the best listeners, trusted co-pilots,
and our favorite playmates.
But make no mistake.
If you own pets,
chances are you've had a pet accident in your home.
Unfortunately,
pet accidents can really affect the health and wellbeing of your home and your family.
How serious can this be to your family's health?
To answer that
we asked acclaimed veterinarian Dr. Kwane Stewart to share his views on the subject.
Pet urine in carpets, rugs, and upholstery or other soft furnishings
can cause noxious odors due to the ammonia contained in the urine,
which can incite respiratory issue and aggravate other conditions
such as asthma and allergies.
On top of that, pet urine can contain bacteria
in the food particles that can be deposited around your home which can result in illness.
I certainly wouldn't want my kids playing on a carpet with pet urine
due to these and other risks just like I wouldn't want them playing on or around a toilet.
What are the facts about pet urine in carpets?
If left untreated,
pet urine penetrates carpet fibers down to the base and into the floor underneath.
As it dries, the liquid evaporates but urine crystals form which cause the strong odor.
Another factor is the the urine can leave behind bacteria as well.
Many consumer products and professional services really just mask the odor
only to have it return later.
But we have good news: Chem-Dry has a solution the really works.
First, we assess whether there is any pet urine in your home
so we can let you know the extent of the issue and determine how to best treat it.
Then we'll use our proprietary PURT process which stands for Pet Urine Removal Treatment.
PURT eliminate the poor at the source, breaking down and exploding urine crystals
and removing them and the odors they cause for good.
Using our hot carbonating extraction process along with a sanitizer, we can also perform
a deep clean down to the base of your carpets to eliminate the dirt residue and bacteria.
In fact, we hired a independent lab to test these Chem-Dry processes.
The lab found that PURT removes 99.9% of pet urine odors in carpets.
And, when combined with our hot carbonating extraction process and a sanitizer,
Chem-Dry removes 99.2% of the bacteria from pet urine in carpets,
leaving your home cleaner and healthier.
Was does Dr. Kwane think of PURT?
We have a miniature schnauzer named Saki and two children in our home
and I certainly don't want those unhealthy elements lingering here.
That's why we trusted Chem-Dry's PURT process in my home.
It got out the odors and bacteria which gives me peace of mind knowing how much time
my little ones spend lying and playing on our carpets and couches.
A healthy home is very important to us.
With Chem-Dry you get a deeper, longer lasting clean and a healthier, happier home.
Chem-Dry: we clean for your health like no one else.
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